Portable impulse-radar detector for breast cancer: a pilot study
Portable impulse-radar detector for breast cancer: a pilot study
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DOI：
10.1117/1.jmi.5.2.025502
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发表时间：
2018-04-01
影响因子：
2.4
通讯作者：
Okada, Morihito
中科院分区：
文献类型：
--
作者：
Sasada, Shinsuke;Masumoto, Norio;Okada, Morihito
微波乳房成像是一种无痛、无辐射的方法。这项初步研究旨在评估使用基于雷达的成像系统的便携式乳腺癌检测器原型的检测能力和可行性。5例经组织学证实的最小直径为1厘米的乳腺癌患者参加了这项研究。该装置的天线阵圆顶以仰卧位放置在患者的乳房上，每次检查15分钟。主要终点是乳腺癌的检测率。次要终点是定位准确性和不良事件。所有五个靶向乳腺肿瘤都被检测到，并在其他诊断方式确认的位置进行了可视化。在5个肿瘤中，1个因乳腺密度不均匀而未通过钼靶摄影发现，另一个是肿瘤大小为0.5 mm的浸润性微小浸润癌。未发生与研究相关的不良事件。便携式乳腺癌检测仪的样机具有足够的检测能力，临床使用是安全的，可以检测早期乳腺癌，如非浸润性癌。未来的发展应该集中在进一步缩小机器的尺寸和缩短检查时间上。(C)2018年光学仪器工程师学会(SPIE)
Microwave breast imaging is a painless and nonradiation method. This pilot study aimed to evaluate the detective capability and feasibility of a prototype of a portable breast cancer detector using a radar-based imaging system. Five patients with histologically confirmed breast cancers with a minimum diameter of 1 cm were enrolled in this study. The antenna array dome of the device was placed on the breast of the patient in a supine position for 15 min per single examination. The primary endpoint was a detection rate of breast cancers. The secondary endpoints were positional accuracy and adverse event. All five targeted breast tumors were detected and were visualized at the sites confirmed by other diagnostic modalities. Among five tumors, one was not detected via mammography because of heterogeneously dense breast and another was a microinvasive carcinoma of invasive tumor size 0.5 mm. No study-related adverse events occurred. The prototype of a portable breast cancer detector has sufficient detective capability, is safe for clinical use, and might detect an early stage breast cancer, such as noninvasive carcinoma. Future developments should focus on further decreasing the size of the machine and shortening inspection time. (c) 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)