Assembly of Substituted 3-Methyleneisoindolin-1-ones via a CuI/L-Proline-Catalyzed Domino Reaction Process of 2-Bromobenzamides and Terminal Alkynes
Assembly of Substituted 3-Methyleneisoindolin-1-ones via a CuI/L-Proline-Catalyzed Domino Reaction Process of 2-Bromobenzamides and Terminal Alkynes
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DOI：
10.1021/ol9000922
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发表时间：
2009-03-19
期刊：
影响因子：
5.2
通讯作者：
Ma, Dawei
中科院分区：
文献类型：
--
作者：
Li, Li;Wang, Miao;Ma, Dawei
CuI/L-脯氨酸催化的2-溴苯甲酰胺和末端炔在PrOH（或DMF和DMSO）中在85-110 ℃下的偶联和随后的加成环化产生取代的3-亚甲基异吲哚啉-1-酮。通过使用合适的起始材料，N-取代基、芳环和亚甲基部分的变化是可能的。
CuI/L-proline catalyzed coupling of 2-bromobenzamides and terminal alkynes in PrOH (or DMF and DMSO) at 85-110 degrees C and subsequent additive cyclization produces substituted 3-methyleneisoindolin-1-ones. Variation of N-substituents, aromatic ring, and methylene part is possible by using suitable starting materials.