Social pain and social gain in the adolescent brain: A common neural circuitry underlying both positive and negative social evaluation.
Social pain and social gain in the adolescent brain: A common neural circuitry underlying both positive and negative social evaluation.
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DOI：
10.1038/srep42010
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发表时间：
2017-02-07
影响因子：
4.6
通讯作者：
Stretton J
中科院分区：
文献类型：
--
作者：
Dalgleish T;Walsh ND;Mobbs D;Schweizer S;van Harmelen AL;Dunn B;Dunn V;Goodyer I;Stretton J
社会互动本质上涉及对社会包容和排斥显著线索的主观评价。神经系统中专门检测身体疼痛的部分，背前扣带皮层（dACC）和前岛叶（AI），已被证明对社会排斥后经历的社会疼痛的检测同样敏感，这证明了这些社会线索的重要性。然而，最近的研究表明，这种dACC-AI矩阵可以索引任何与社会相关的信息。我们直接测试了dACC-AI会对包容和排斥的线索做出反应的假设，在青少年群体中使用了一种新的社会反馈fMRI范式。我们发现，dACC和左AI通常被包含和排除的反馈线索激活。我们的研究结果表明，dACC-AI网络作为一种神经报警系统，在社会领域内仅限于排除信号的处理，这一理论解释需要进行重大修订。
Social interaction inherently involves the subjective evaluation of cues salient to social inclusion and exclusion. Testifying to the importance of such social cues, parts of the neural system dedicated to the detection of physical pain, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been shown to be equally sensitive to the detection of social pain experienced after social exclusion. However, recent work suggests that this dACC-AI matrix may index any socially pertinent information. We directly tested the hypothesis that the dACC-AI would respond to cues of both inclusion and exclusion, using a novel social feedback fMRI paradigm in a population-derived sample of adolescents. We show that the dACC and left AI are commonly activated by feedback cues of inclusion and exclusion. Our findings suggest that theoretical accounts of the dACC-AI network as a neural alarm system restricted within the social domain to the processing of signals of exclusion require significant revision.