Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
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DOI：
10.1038/nrgastro.2016.51
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发表时间：
2016-05-01
影响因子：
65.1
通讯作者：
Alvaro, Domenico
中科院分区：
文献类型：
--
作者：
Banales, Jesus M.;Cardinale, Vincenzo;Alvaro, Domenico
胆管癌是一组异质性的恶性肿瘤，具有胆道分化的特征。CCA是第二常见的原发性肝脏肿瘤，其发病率在全球范围内呈上升趋势。由于其侵袭性、诊断晚和难治性，CCA的死亡率很高。2015年5月，创建了“欧洲胆管癌研究网络”（ENS-CCA：www.enscca.org或www.cholangiocarcinoma.eu），以促进和推动在基础，转化和临床水平上研究CCA的国际研究合作。在这份共识声明中，我们的目标是提供有关分类，病理特征，风险因素，起源细胞，遗传和表观遗传修饰以及目前可用于这种癌症的治疗方法的有价值的信息。此外，强调了ENS-CCA的基础和临床研究和计划的未来方向。
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the "European Network for the Study of Cholangiocarcinoma" (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level. In this Consensus Statement, we aim to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer. Moreover, future directions on basic and clinical investigations and plans for the ENS-CCA are highlighted.