THE SOLITARY PULMONARY NODULE - UPDATE 1995
THE SOLITARY PULMONARY NODULE - UPDATE 1995
复制标题
DOI：
10.1016/s0002-9343(99)80225-3
复制
发表时间：
1995-11-01
影响因子：
5.9
通讯作者：
YANKELEVITZ, DF
中科院分区：
文献类型：
--
作者：
LIBBY, DM;HENSCHKE, CI;YANKELEVITZ, DF
目得：本研究分析了1990 ~ 1993年某城市大学附属医院肺病科门诊中发现的孤立性肺结节（SPN）患者的临床特征、诊断评估、恶性肿瘤的患病率和预后。患者和方法：SPN定义为肺实质内直径小于或等于3cm的圆形或卵圆形密度。结果：40例患者平均年龄65岁，性别分布几乎相等，心血管疾病（53%）和慢性阻塞性肺疾病（COPD）（33%）的患病率较高，但结核病的发病率较低。孤立性结节的平均大小为1.8cm。恶性肿瘤的患病率为53%。在直径小于或等于2cm的SPN中，恶性肿瘤的患病率为43%。非手术活检技术在78%的患者中做出了诊断。在94%的SPN肺癌患者中，肿瘤是可切除的（1、2或3A期），强调了早期发现的必要性。尽管小尺寸的SPN，恶性肿瘤的患病率是high.CONCLUSION：尽管高龄和高患病率的心血管疾病和COPD患者的SPN，肺癌发生在这些病变似乎有一个良好的预后，如果及时检测。
PURPOSE: This study analyzed the clinical characteristics, diagnostic evaluation, prevalence of malignancy, and outcome of patients with a solitary pulmonary nodule (SPN) encountered in the outpatient practice of a pulmonologist in an urban university hospital from 1990 to 1993.PATIENTS AND METHODS: SPN was defined as a round or ovoid density less than or equal to 3 cm in diameter within the lung parenchyma. Patients with and without lung cancer in SPNs were compared.RESULTS: Forty patients had a mean age of 65 years, an almost equal sex distribution, high prevalences of cardiovascular disease (53%) and chronic obstructive pulmonary disease (COPD) (33%), but a low incidence of tuberculosis. The mean size of SPNs was 1.8 cm. The prevalence of malignancy was 53%. In SPNs less than or equal to 2 cm in diameter, the prevalence of malignancy was 43%. Nonsurgical biopsy techniques made a diagnosis in 78% of patients. In 94% of patients with lung cancer in SPNs, the tumor was resectable (stage 1, 2, or 3A), emphasizing the need for early detection. Despite the small size of the SPNs, the prevalence of malignancy was high.CONCLUSION: Despite the advanced age and high prevalence of cardiovascular disease and COPD in patients with SPNs, lung cancer that occurs in these lesions appears to have a favorable prognosis if detected promptly.