CXCL3 is a Potential Target for Breast Cancer Metastasis
CXCL3 is a Potential Target for Breast Cancer Metastasis
复制标题
DOI：
10.2174/1568009614666140305222328
复制
发表时间：
2014-01-01
影响因子：
3
通讯作者：
Lim, Yoon Pin
中科院分区：
文献类型：
--
作者：
See, Amanda Lay Pin;Chong, Poh Kuan;Lim, Yoon Pin
分泌蛋白是癌症药物靶点的一个有吸引力的雷区。采用基于iTRAQ的串联质谱法对具有增加的转移潜能的四种等基因乳腺癌细胞系的分泌组中的蛋白质进行相对定量。发现CXCL3在侵袭性癌细胞中上调。SiRNA和抗体中和研究支持CXCL3在转移过程中的作用。对1881例乳腺肿瘤中CXCL3 mRNA水平的荟萃分析支持CXCL3在临床乳腺癌中的作用。我们的研究结果支持CXCL3在乳腺癌转移中的功能作用，并作为癌症治疗的可行靶点。
Secreted proteins are an attractive minefield for cancer drug targets. An iTRAQ-based tandem mass spectrometry approach was employed to relatively quantify proteins in the secretomes of four isogenic breast cancer cell lines with increasing metastatic potential. CXCL3 was found to be upregulated in aggressive cancer cells. SiRNA and antibody neutralization studies supported a role of CXCL3 in metastatic processes. Meta-analysis of the mRNA level of CXCL3 in 1881 breast tumors supported a role of CXCL3 in clinical breast cancer. Our results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy.