No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traits
No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traits
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DOI：
10.1016/j.schres.2006.06.029
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发表时间：
2006-10-01
影响因子：
4.5
通讯作者：
Sasaki, Tsukasa
中科院分区：
文献类型：
--
作者：
Tochigi, Mamoru;Otowa, Takeshi;Sasaki, Tsukasa
脑源性神经营养因子(BDNF)是神经生长因子家族中的一员，在神经发育中起着至关重要的作用。根据神经发育假说，BDNF基因是精神分裂症的候选基因。在高加索人中，最近的研究发现与Val66Met多态有关，该多态被认为影响人类的情景记忆和海马体功能。然而，在其他人群中，这种关联并未被复制。在本研究中，我们调查了401例日本精神分裂症患者和569名对照组中该基因Val66Met多态与精神分裂症的关系。因此，我们没有观察到患者和对照组之间的基因分布和等位基因频率的差异(分别为chi(2)=0.56，df=2，p=0.76和chi(2)=0.39，df=1，p=0.53)。我们还调查了对照组中基因多态与人格特征之间的关联；然而，没有观察到显著的关联。因此，本研究没有提供日本人群中BDNF基因与精神分裂症或人格特征之间存在关联的证据。(C)2006爱思唯尔B.V.保留所有权利。
Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, which plays a critical role in neurodevelopment. Based on the neurodevelopmental hypothesis, the BDNF gene has been a candidate locus for schizophrenia. In Caucasians, recent studies identified an association with the Val66Met polymorphism, which has been suggested to affect episodic memory and hippocampal function in humans. However, in other populations, the association has not been replicated. In the present study, we investigated the association between the Val66Met polymorphism of the gene and schizophrenia in 401 Japanese patients with schizophrenia and 569 controls. As a result, we did not observe a significant difference in genotypic distribution or allele frequencies between the patients and controls (chi(2) = 0.56, df = 2, p = 0.76 and chi(2) = 0.39, df = 1, p = 0.53, respectively). We also investigated the association between the polymorphism and personality traits in the controls; however, no significant association was observed. Thus, the present study did not provide evidence for an association between the BDNF gene and schizophrenia or personality traits in the Japanese population. (c) 2006 Elsevier B.V. All rights reserved.