Effect of baseline glomerular filtration rate on survival in patients undergoing partial or radical nephrectomy for renal cortical tumors
Effect of baseline glomerular filtration rate on survival in patients undergoing partial or radical nephrectomy for renal cortical tumors
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DOI：
10.4065/83.10.1101
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发表时间：
2008-10-01
影响因子：
8.9
通讯作者：
Russo, Paul
中科院分区：
文献类型：
--
作者：
Pettus, Joseph A.;Jang, Thomas L.;Russo, Paul
目的：探讨基线肾功能和共病指数对肾肿瘤患者生存率的影响。方法：检索1995年1月4日至2005年6月9日因局限性肾肿瘤行部分或根治性肾切除术的1479例患者的人口学、临床病理、体重指数(BMI)和共病资料(用Charlson-Romano指数和高血压进行评估)。我们使用简化的改良饮食和肾脏疾病方程来估计肾小球滤过率(EGFR)，使用最后一次术前血清肌酐测量。对体重指数和EGFR时间趋势进行线性回归分析。结果：在10年的时间间隔中，中位数BMI从27(四分位数范围[IQR]，24-31)增加到28(IQR，25-31；P=0.004)，而基线EGFR从70(IQR，58-80)下降到63 mL/min/1.73 m(2)(IQR，57-78；P=0.004)。
OBJECTIVE: To evaluate the effect of baseline renal function and comorbidity index on survival in patients with renal tumors.PATIENTS AND METHODS: We retrieved demographic, clinicopathologic, body mass index (BMI), and comorbidity data (assessed by Charlson-Romano index and hypertension) for 1479 patients who underwent partial or radical nephrectomy between January 4, 1995, and June 9, 2005, for localized renal tumors. We used the abbreviated Modified Diet and Renal Disease equation to estimate glomerular filtration rate (eGFR) using the last preoperative serum creatinine measurement. Body mass index and eGFR time trends were analyzed with linear regression. The effect of BMI, comorbidity, and baseline eGFR on disease-free and overall survival was studied using Cox regression controlling for pathologic stage, nodal status, and metastasis.RESULTS: Over a 10-year interval, median BMI increased from 27 (interquartile range [IQR], 24-31) to 28 (IQR, 25-31; P=.004), and median baseline eGFR decreased from 70 (IQR, 58-80) to 63 mL/min per 1.73 m(2) (IQR, 57-78; P