TIM family proteins and autoimmunity

TIM family proteins and autoimmunity
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DOI:
10.1080/08916930701464871
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发表时间:
2007-01-01
期刊:
影响因子:
3.5
通讯作者:
Kane, Lawrence P.
Kane, Lawrence P.
中科院分区:
医学4区
文献类型:
--
作者:
Kane, Lawrence P.

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尽管它们相对新鲜,但现在越来越多的文献表明,T细胞免疫球蛋白和粘蛋白结构域(TIM)家族蛋白是免疫的重要调节因子。不足为奇的是,这些蛋白质在控制自身反应性免疫反应方面也发挥着重要作用。因此,调节TIM蛋白的功能可能被证明是控制自身免疫性疾病的有用策略。
Despite their relative novelty, a growing body of literature now demonstrates that T cell immunoglobulin and mucin domain (TIM) family proteins are important regulators of immunity. Not surprisingly, these proteins also play prominent roles in the control of auto-reactive immune responses. Thus, modulation of TIM protein function may prove to be a useful strategy to control autoimmune diseases.