Cadherin-1, -2, and -11 expression and cadherin-2 function in the pectoral limb bud and fin of the developing zebrafish.
Cadherin-1, -2, and -11 expression and cadherin-2 function in the pectoral limb bud and fin of the developing zebrafish.
复制标题
钙粘蛋白-1、-2 和-11 在发育中的斑马鱼的胸肢芽和鳍中的表达和钙粘蛋白-2 的功能。
DOI：
10.1002/dvdy.10401
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Marrs,JA
中科院分区：
文献类型：
--
作者：
Liu,Q;Kerstetter,AE;Azodi,E;Marrs,JA
Cadherins are cell adhesion molecules that play important roles in development of a variety of organs, including the vertebrate limb. In this study, we analyze cadherin expression patterns in the embryonic zebrafish pectoral limb buds and larval pectoral fins by using both in situ hybridization and immunocytochemical methods.cadherin‐1is detected in the epidermis of the embryonic limb buds and the larval pectoral fins. Cadherin‐2 is expressed in the pectoral limb bud mesenchyme and chondrogenic condensation. As development proceeds, cadherin‐2 expression is detected in newly differentiated pectoral fin endoskeleton, but its expression is greatly down‐regulated in the fin endoskeleton of larval zebrafish.cadherin‐11is found in the basal region of the embryonic limb buds and in the proximal endoskeleton of the larval pectoral fins. Interfering with cadherin‐2 function using two specific antisense morpholino oligonucleotides disrupts formation of the chondrogenic condensation/endoskeleton, suggesting that cadherin‐2 is crucial for the normal development of the zebrafish pectoral fins. Developmental Dynamics 228:734–739, 2003. © 2003 Wiley‐Liss, Inc.
