Rapid Delivery of Drug Carriers Propelled and Navigated by Catalytic Nanoshuttles
Rapid Delivery of Drug Carriers Propelled and Navigated by Catalytic Nanoshuttles
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DOI：
10.1002/smll.201001257
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发表时间：
2010-12-06
期刊：
影响因子：
13.3
通讯作者：
Wang, Joseph
中科院分区：
文献类型：
--
作者：
Kagan, Daniel;Laocharoensuk, Rawiwan;Wang, Joseph
本文报道了首次使用催化纳米穿梭体来获取、运输和释放常见药物载体（包括生物相容性和可生物降解的聚合物颗粒和脂质体）的概念验证。大尺寸载药颗粒（100 nm-3.0 μ m）的快速运输速度比布朗运动的速度快约3个数量级，证明了纳米航天飞机的高推进力。纳米穿梭体的导航能力由药物载体通过微通道从拾取到释放微孔的运输来说明。纳米马达将载药聚合物颗粒和脂质体快速运送到目标目的地的能力代表了一种以靶向方式运输药物载体的新方法。这也有可能解决当前纳米颗粒药物递送的障碍，例如颗粒的脱靶。虽然在本文中初步提出了在体外主动输送治疗颗粒的概念，但未来的努力将集中在与无燃料纳米载体相关的实际体内基于运动的靶向药物输送上。
This paper reports the first proof-of-concept of using catalytic nanoshuttles to pick up, transport, and release common drug carriers including biocompatible and biodegradable polymeric particles and liposomes. The rapid transport of a wide size range of drug-loaded particles (100 nm-3.0 mu m) with a speed approximately three orders of magnitude faster than that of the particles transported by Brownian motion demonstrates the high propulsion power of the nanoshuttles. The nanoshuttles' navigation ability is illustrated by the transport of the drug carriers through a microchannel from the pick-up to the release microwell. Such ability of nanomotors to rapidly deliver drug-loaded polymeric particles and liposomes to their target destination represents a novel approach towards transporting drug carriers in a target-specific manner. This also potentially addresses the obstacles of current nano particle drug delivery, such as off-targeting of particles. While an initial concept of actively transporting therapeutic particles is demonstrated in vitro in this paper, future efforts will focus on practical in vivo motor-based targeted drug delivery in connection to fuel-free nanovehicles.