Macroautophagy and aging: The impact of cellular recycling on health and longevity.
Macroautophagy and aging: The impact of cellular recycling on health and longevity.
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DOI：
10.1016/j.mam.2021.101020
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发表时间：
2021-12
影响因子：
10.6
通讯作者：
Hansen M
中科院分区：
文献类型：
--
作者：
Nieto-Torres JL;Hansen M
衰老与细胞水平上的许多有害变化有关，包括可能对健康产生破坏性影响的潜在有毒成分的积累。为此目的的一个关键保护机制是称为自噬的细胞回收过程。在自噬过程中，受损或多余的细胞成分被传递到称为溶酶体的酸性囊泡中，以确保成分的降解和回收。自噬和衰老之间存在许多联系。自噬随着年龄的增长而下降，越来越多的证据表明，这种减少在生理衰老和与年龄相关的疾病的发展中发挥着重要作用。对药理学和基因操纵模型生物的研究表明，自噬缺陷会促进与年龄相关的疾病，相反，自噬的增强对健康和寿命都有有益影响。在这里，我们回顾了目前对自噬在不同生理过程中的作用及其与衰老和年龄相关疾病的分子联系的理解。我们还强调了该领域的一些最新进展，这些进展可以加速基于自噬的治疗干预措施的发展。
Aging is associated with many deleterious changes at the cellular level, including the accumulation of potentially toxic components that can have devastating effects on health. A key protective mechanism to this end is the cellular recycling process called autophagy. During autophagy, damaged or surplus cellular components are delivered to acidic vesicles called lysosomes, that secure degradation and recycling of the components. Numerous links between autophagy and aging exist. Autophagy declines with age, and increasing evidence suggests that this reduction plays important roles in both physiological aging and the development of age-associated disorders. Studies in pharmacologically and genetically manipulated model organisms indicate that defects in autophagy promote age-related diseases, and conversely, that enhancement of autophagy has beneficial effects on both healthspan and lifespan. Here, we review our current understanding of the role of autophagy in different physiological processes and their molecular links with aging and age-related diseases. We also highlight some recent advances in the field that could accelerate the development of autophagy-based therapeutic interventions.
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DOI：
10.1083/jcb.201610113
发表时间：
2017-07-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Carroll B;Nelson G;Rabanal-Ruiz Y;Kucheryavenko O;Dunhill-Turner NA;Chesterman CC;Zahari Q;Zhang T;Conduit SE;Mitchell CA;Maddocks ODK;Lovat P;von Zglinicki T;Korolchuk VI
通讯作者：
Korolchuk VI
DOI：
10.1152/physiol.00010.2011
发表时间：
2011-08
期刊：
Physiology (Bethesda, Md.)
影响因子：
--
作者：
Cantó C;Auwerx J
通讯作者：
Auwerx J
影响因子：
17.1
作者：
Cao, Kan;Graziotto, John J.;Collins, Francis S.
通讯作者：
Collins, Francis S.
影响因子：
7.8
作者：
Bejarano E;Murray JW;Wang X;Pampliega O;Yin D;Patel B;Yuste A;Wolkoff AW;Cuervo AM
通讯作者：
Cuervo AM
影响因子：
8.8
作者：
Aparicio, Ricardo;Rana, Anil;Walker, David W.
通讯作者：
Walker, David W.