Concordant and discordant coding of spatial location in populations of hippocampal CA1 pyramidal cells
Concordant and discordant coding of spatial location in populations of hippocampal CA1 pyramidal cells
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DOI：
10.1152/jn.2002.88.4.1605
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发表时间：
2002-10-01
影响因子：
2.5
通讯作者：
Skaggs, WE
中科院分区：
文献类型：
--
作者：
Brown, JE;Skaggs, WE
大鼠海马体中的锥体细胞通常表现出与位置相关的活动，但很难理解控制它们的因素。一个特别重要的问题是，单个细胞是否具有可识别的相关因子，可以独立于其他细胞的相关因子进行操作。最近，Tanila等人研究了在迷宫中奔跑的大鼠海马小群细胞的活动，这些细胞具有不同的迷宫内和迷宫外线索。当两组线索在相反方向旋转90度时，一些细胞遵循惊奇内线索，另一些遵循惊奇外线索，还有一些不可预测地“重新定位”；此外，在同时记录的合奏中可以看到所有可能的组合。在目前的研究中，使用一种允许同时记录4-70个单位的记录系统，以类似的模式记录了4只大鼠的CA1锥体细胞群活动。结果与早期研究的数据一致，即随着时间的推移，重新定位的情况有所增加，并且显示一些位置域遵循一组已定义的线索，而另一些位置域则重新定位。然而，当控制随机重新映射的可能性时，分析并没有显示同时遵循两组线索的位置场的显著数量。此外，所有的大鼠最初都表现出完全一致的反应，所有的地方场都遵循当地的线索。对于两只大鼠来说，这种模式一直持续到引入一种新的配置，此时所有的脑区都跟随远端线索切换。综上所述，这些结果很难与单个海马细胞编码环境中不同线索子集信息的假设相一致。
Pyramidal cells in the rat hippocampus commonly show place-related activity, but it has been difficult to understand the factors that govern them. A particularly important question is whether individual cells have identifiable correlates that can be manipulated independently of the correlates of other cells. Recently Tanila et al. examined the activity of small ensembles of hippocampal cells in rats running on a plus-maze with distinct intra- and extramaze cues. When the two sets of cues were rotated 90degrees in opposite directions, some cells followed the intramaze cues, others followed the extramaze cues, and others "remapped" unpredictably; moreover, all possible combinations were seen within simultaneously recorded ensembles. In the current study, CA1 pyramidal cell population activity was recorded from four rats in a similar paradigm, using a recording system that permitted the analysis of ensembles of 4-70 simultaneously recorded units. The results were consistent with the data from the earlier study in showing an increase in remapping over time and in showing some place fields following one of the defined sets of cues while others remapped. When the possibility of random remapping was controlled for, however, the analysis did not show significant numbers of place fields following both sets of cues simultaneously. Furthermore, all rats initially showed fully concordant responses with all place fields following the local cues. For two rats, this pattern continued until a new configuration was introduced at which time all fields switched to follow the distal cues. Taken together, the results are difficult to reconcile with the hypothesis that individual hippocampal cells encode information about different subsets of cues in the environment.