Auditory midbrain neurons that count
Auditory midbrain neurons that count
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DOI：
10.1038/nn916
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发表时间：
2002-10-01
影响因子：
25
通讯作者：
Rose, GJ
中科院分区：
文献类型：
--
作者：
Edwards, CJ;Alder, TB;Rose, GJ
许多声学通信信号，包括人类的语音和音乐，由离散元素的精确时间排列组成，但目前还不清楚这种精确的时间模式是否需要激活介导信号识别的感觉神经元。在各种系统中，当两个或更多的声音元素以特定的时间顺序出现时，神经元会选择性地做出反应，这些元素的精确相对定时对于蝙蝠中的“延迟调谐”神经元（包括“跟踪”类型）尤为重要。在这里，我们表明，一类听觉神经元在中脑的无尾两栖动物（青蛙和蟾蜍）只响应一系列特定的脉冲间间隔（IPIs），在最有选择性的情况下，一个单一的间隔，这是略长或略短于必要的间隔可以重置这个间隔计数过程。
Many acoustic communication signals, including human speech and music, consist of a precise temporal arrangement of discrete elements, but it is unclear whether this precise temporal patterning is required to activate the sensory neurons that mediate signal recognition. In a variety of systems, neurons respond selectively when two,,or more sound elements are presented in a particular temporal order and the precise relative timing of these elements is particularly important for 'delay-tuned' neurons, including 'tracking' types, in bats. Here we show that one class of auditory neurons in the midbrain of anurans (frogs and toads) responds only to a series of specific interpulse intervals (IPIs); in the most selective cases, a single interval that is slightly longer or shorter than the requisite interval can reset this interval-counting process.