Three dimensional first-pass myocardial perfusion imaging at 3T: feasibility study
Three dimensional first-pass myocardial perfusion imaging at 3T: feasibility study
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DOI：
10.1186/1532-429x-10-57
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发表时间：
2008-12-11
影响因子：
6.4
通讯作者：
Nayak, Krishna S.
中科院分区：
文献类型：
--
作者：
Shin, Taehoon;Hu, Houchun H.;Nayak, Krishna S.
背景资料：在缺血性心脏病患者中，准确评估心肌灌注不足的程度可能对预测临床心脏结局的预后很重要。本研究的目的是比较三维（3D）和二维（2D）多层心肌灌注成像（MPI）使用心血管磁共振（CMR）确定缺损大小的能力，并证明3D MPI在健康志愿者中在3特斯拉下的可行性。方法：使用心脏体模比较3D和2D多层MPI在估计模拟透壁心肌灌注缺损的七个橡胶插入物的体积分数方面的准确性。采集三组横截面平面进行2D多层成像，其中每组沿分区编码方向移动沿着+/- 10 mm。在三名志愿者中进行3D首过对比增强（0.1 mmol/kg Gd-DTPA）MPI，灵敏度编码为6倍加速度。结果：在3D、2D 4层和2D 3层成像中，估计7个缺损的心肌体积分数的平均误差/标准差分别为-0.44/1.49%，2.23/2.97%，2.59/3.18%。在健康志愿者中进行的3D MPI产生了覆盖整个左心室（LV）的高质量图像。前8层所有节段的峰值SNR/CNR分别为57.6 ± 22.0/37.5 ± 19.7。结论：3D在估计体模中灌注缺损的大小方面优于2D多层MPI。在3 T下的高加速3D MPI在志愿者中是可行的，允许整个LV覆盖，图像质量优良，SNR/CNR高。
Background: In patients with ischemic heart disease, accurate assessment of the extent of myocardial perfusion deficit may be important in predicting prognosis of clinical cardiac outcomes. The aim of this study was to compare the ability of three dimensional (3D) and of two dimensional (2D) multi-slice myocardial perfusion imaging (MPI) using cardiovascular magnetic resonance (CMR) in determining the size of defects, and to demonstrate the feasibility of 3D MPI in healthy volunteers at 3 Tesla.Methods: A heart phantom was used to compare the accuracy of 3D and 2D multi-slice MPI in estimating the volume fraction of seven rubber insets which simulated transmural myocardial perfusion defects. Three sets of cross-sectional planes were acquired for 2D multi-slice imaging, where each set was shifted along the partition encoding direction by +/- 10 mm. 3D first-pass contrast-enhanced (0.1 mmol/kg Gd-DTPA) MPI was performed in three volunteers with sensitivity encoding for six-fold acceleration. The upslope of the myocardial time-intensity-curve and peak SNR/CNR values were calculated.Results: Mean/standard deviation of errors in estimating the volume fraction across the seven defects were -0.44/1.49%, 2.23/2.97%, and 2.59/3.18% in 3D, 2D 4-slice, and 2D 3-slice imaging, respectively. 3D MPI performed in healthy volunteers produced excellent quality images with whole left ventricular (LV) coverage. Peak SNR/CNR was 57.6 +/- 22.0/37.5 +/- 19.7 over all segments in the first eight slices.Conclusion: 3D performed better than 2D multi-slice MPI in estimating the size of perfusion defects in phantoms. Highly accelerated 3D MPI at 3T was feasible in volunteers, allowing whole LV coverage with excellent image quality and high SNR/CNR.