Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with Age of Puberty among Children Living near a Chemical Plant
Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with Age of Puberty among Children Living near a Chemical Plant
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DOI：
10.1021/es1038694
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发表时间：
2011-10-01
影响因子：
11.4
通讯作者：
Leonardi, Giovanni
中科院分区：
文献类型：
--
作者：
Lopez-Espinosa, Maria-Jose;Fletcher, Tony;Leonardi, Giovanni
动物研究表明，全氟化碳（PFC）可能会改变性成熟。人类PFC暴露与青春期的关系尚不清楚。我们进行了一项横断面研究，调查是否全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）与性成熟的指标在2005-2006年的调查与PFOA水污染的居民从俄亥俄州中部山谷。参与者是3076名8-18岁的男孩和2931名女孩。根据激素水平（男孩中总睾酮>50 ng/dL和游离睾酮>5 pg/mL，女孩中雌二醇>20 pg/mL）或初潮开始，将他们分类为已进入青春期。我们估计了根据这些标准分类的进入青春期的几率，以及进入青春期的拟合中位年龄与分配青春期状态时测量的血清PFOA和PFOS浓度的关系。对于男孩来说，进入青春期的几率降低（睾丸激素增加）与全氟辛烷磺酸增加（最高和最低四分位数之间延迟190天）有关。对于女孩来说，较高浓度的全氟辛酸或全氟辛烷磺酸与月经初潮后的可能性降低有关（分别延迟130天和138天）。总之，我们的研究表明，在这个人群中，较晚的青春期年龄与PFC浓度相关。
Animal studies suggest that perfluorocarbons (PFCs) may alter sexual maturation. Relationships of human PFC exposure with puberty are not clear. We conducted a cross-sectional study to investigate whether perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) were associated with indicators of sexual maturation in a 2005-2006 survey of residents with PFOA water contamination from the Mid-Ohio Valley. Participants were 3076 boys and 2931 girls 'aged 8-18 years. They were classified as having reached puberty based on either hormone levels (total >50 ng/dL and free >5 pg/mL testosterone in boys and estradiol >20 pg/mL in girls) or onset of menarche. We estimated the odds of having reached puberty classified by these criteria and the fitted median age of reaching puberty in relation to serum PFOA and PFOS concentrations measured when puberty status was assigned. For boys, there was a relationship of reduced odds of reached puberty (raised testosterone) with increasing PFOS (delay of 190 days between the highest and lowest quartile). For girls, higher concentrations of PFOA or PFOS were associated with reduced odds of postmenarche (130 and 138 days of delay, respectively). In conclusion, our study showed a later age of puberty in this population correlated with PFC concentrations.