The Warburg effect: A new insight into atrial fibrillation
The Warburg effect: A new insight into atrial fibrillation
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DOI：
10.1016/j.cca.2019.08.029
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Qiming Liu
中科院分区：
文献类型：
--
作者：
Yaozhong Liu;Fan Bai;Na Liu;Feifan Ouyang;Qiming Liu
Atrial fibrillation (AF) is the most common sustained arrhythmia. Atrial remodeling, including electrical/.structural/autonomic remodeling, plays a vital role in AF pathogenesis. All of these have been shown to con-.tribute continuously to the self-perpetuating nature of AF. The Warburg effect was found to play important roles.in tumor and non-tumor disease. Recently, lots of studies documented altered atrial metabolism in AF, but the.specific mechanism and the impact of these changes upon AF initiation/progression remain unclear. In this.article, we review the metabolic consideration in AF comprehensively and observe the footprints of the Warburg.effect. We also summarize the signaling pathway involved in the Warburg effect during AF—HIF-1α and AMPK,.and discuss their potential roles in AF maintenance and progression. In conclusion, we give the innovative idea.that the Warburg effect exists in AF and promotes the progression of AF. Targeting it may provide new therapies.for AF treatment.
