Sensor integration of multiple tripolar concentric ring electrodes improves pentylenetetrazole-induced seizure onset detection in rats.
Sensor integration of multiple tripolar concentric ring electrodes improves pentylenetetrazole-induced seizure onset detection in rats.
复制标题
多个三极同心环电极的传感器集成改善了戊四唑诱导的大鼠癫痫发作检测。
DOI：
10.1109/embc.2012.6347154
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Besio,WalterG
中科院分区：
文献类型：
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作者：
Makeyev,Oleksandr;Ding,Quan;Kay,StevenM;Besio,WalterG
由于癫痫影响世界人口的大约百分之一，大脑的电刺激最近显示出附加癫痫控制治疗的潜力。在此之前，我们应用非侵入性经颅局灶性刺激通过三极同心环电极在大鼠头皮上诱导癫痫发作后，戊四唑。我们开发了一个系统，以检测癫痫发作和自动触发的刺激和评估系统的电图活动从大鼠。在这项初步研究中，我们提出并验证了一种新的癫痫发作检测算法的基础上指数嵌入的家庭。与先前提出的方法不同，它集成了来自多个电极的数据，从而提高了检测器的性能。
As epilepsy affects approximately one percent of the world population, electrical stimulation of the brain has recently shown potential for additive seizure control therapy. Previously, we applied noninvasive transcranial focal stimulation via tripolar concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole. We developed a system to detect seizures and automatically trigger the stimulation and evaluated the system on the electrographic activity from rats. In this preliminary study we propose and validate a novel seizure onset detection algorithm based on exponentially embedded family. Unlike the previously proposed approach it integrates the data from multiple electrodes allowing an improvement of the detector performance.