To the heart of myofibril assembly
To the heart of myofibril assembly
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DOI：
10.1016/s0962-8924(00)01793-1
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发表时间：
2000-09-01
影响因子：
19
通讯作者：
Antin, PB
中科院分区：
文献类型：
--
作者：
Gregorio, CC;Antin, PB
细胞骨架组装最引人入胜的例子之一是肌原纤维，它是横纹肌(即骨骼肌和心肌)的收缩结构。肌原纤维由被称为肌节的重复收缩单位组成，这可能是真核细胞中最有序的大分子结构。当骨骼肌细胞和心肌细胞分化时，数以千计的结构和调节分子组装成半结晶的肌节收缩单位。作为这种精确组装的结果，许多不同类别的蛋白质共同发挥作用，将肌动蛋白和肌球蛋白的分子相互作用有效地转化为收缩活动的宏观运动。
One of the most fascinating examples of cytoskeletal assembly is the myofibril, the contractile structure of striated (i.e. skeletal and cardiac) muscle. Myofibrils are composed of repeating contractile units known as sarcomeres, perhaps the most highly ordered macromolecular structures in eukaryotic cells. When skeletal and cardiac muscle cells differentiate, thousands of structural and regulatory molecules assemble into the semicrystalline sarcomeric contractile units. As a consequence of this precise assembly, many different classes of proteins function together to convert the molecular interactions of actin ann myosin efficiently into the macroscopic movements of contractile activity.