Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population: A STROBE-Compliant Observational Study.
Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population: A STROBE-Compliant Observational Study.
复制标题
Megsin 基因变异与中国西北人群 IgA 肾病的关联符合 STROBE 的观察性研究
DOI：
10.1097/md.0000000000002694
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发表时间：
2016-02
期刊：
影响因子：
1.6
通讯作者：
Dai ZJ
中科院分区：
文献类型：
--
作者：
Wei LT;Fu RG;Gao J;Yu QL;Dong FM;Wang Z;Wang M;Liu XH;Dai ZJ
Megsin是一种肾小球系膜细胞优势基因，编码丝氨酸蛋白酶抑制剂家族蛋白，在肾系膜中表达。在伊加肾病（IgAN）患者的肾小球中观察到megsin的过表达。本研究的目的是评估megsin基因多态性（rs 1055901和rs 1055902）与中国人群IgAN的关联。我们检查了351例经组织学证实的IgAN患者，并将其与310例年龄、性别和种族匹配的健康受试者进行了比较。采用Sequenom MassARRAY对megsin的两个单核苷酸多态性（SNP）进行基因分型。用SPSS18.0进行统计学分析，用SNP Stats检验这些多态性与IgAN风险之间的关联。比值比和95%置信区间用于评估关系。结果发现rs 1055901和rs 1055902单核苷酸多态性与中国西北地区人群IgA肾病易感性无关。基因型与临床变量之间的关系分析表明，在IgAN患者中，rs 1055901与24小时蛋白尿、血压升高和Lee分级相关（P分别为0.04、0.02和0.04），rs 1055902与24小时蛋白尿和Lee分级相关（P分别为0.03和0.01）。 然而，结果显示这些基因变异与患者的性别之间没有联系。这些结果表明，megsin基因变异可能在中国西北地区人群IgAN的严重程度，发展和/或进展中发挥作用。
Megsin is a mesangial cell-predominant gene that encodes a serpin family protein which is expressed in the renal mesangium. Overexpression of megsin has been observed in the glomeruli of patients with IgA nephropathy (IgAN). The aim of this study was to evaluate the association of megsin polymorphisms (rs1055901 and rs1055902) with IgAN in a Chinese population. We examined 351 patients with histologically proven IgAN and compared them with 310 age, sex, and ethnicity-matched healthy subjects. Two single nucleotide polymorphisms (SNPs) in megsin were genotyped by Sequenom MassARRAY. SPSS 18.0 was used for statistical analyses, and SNP Stats to test for associations between these polymorphisms and IgAN risk. Odds ratios with 95% confidence intervals were used to assess the relationships. We found that rs1055901 and rs1055902 SNPs were not correlated with susceptibility to IgAN in Northwest Chinese population. Analyses of the relationship between genotypes and clinical variables indicated that in patients with IgAN, rs1055901 was associated with 24-hour proteinuria, an increase in blood pressure, and Lee's grade (P = 0.04, 0.02, and 0.04, respectively), and rs1055902 was associated with 24-hour proteinuria and Lee's grade (P = 0.03 and 0.01, respectively). However, the results showed no association between these gene variants and sex of the patients. These results indicate that megsin gene variants may play a role in the severity, development, and/or progression of IgAN in Northwest Chinese population.