Aggregation of a double hydrophilic block glycopolymer: the effect of block polymer ratio
Aggregation of a double hydrophilic block glycopolymer: the effect of block polymer ratio
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DOI：
10.1039/d0tb02093a
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发表时间：
2020-11-28
影响因子：
7
通讯作者：
Miura, Yoshiko
中科院分区：
文献类型：
--
作者：
Oh, Takahiro;Hoshino, Yu;Miura, Yoshiko
双亲水嵌段糖共聚物(DHBGs)是由糖聚合物和聚乙二醇聚合体在水溶液中形成的。然而，没有指导和设计DHBG聚合的指南。在这里，我们研究了糖共聚物长度与聚乙二醇长度的比例对结构的影响，并报告了结构尺寸可能会受到嵌段聚合物比例的影响。通过可逆加成-断裂链转移(RAFT)聚合，合成了9种不同聚乙二醇链长度和不同糖共聚物的DHBG。用透射电子显微镜(TEM)和动态光散射(DLS)研究了DHBG的聚集能力。在所有情况下，DHBG形成了球形结构，即使当聚乙二醇和糖共聚物的长度非常不同时也是如此。结构的大小由聚乙二醇长度与糖共聚物长度的比例控制。DHBG的聚集是由糖基之间的氢键引起的。DHBG的聚集受温度和浓度的影响。
Double hydrophilic block glycopolymers (DHBGs) composed of glycopolymers and polyethylene glycol (PEG) aggregate in aqueous solution. However, there are no guidelines to direct and design DHBG aggregation. Herein, we investigated the effect of the ratio of glycopolymer length to PEG length on the structure, and report that structure size could be influenced by the block polymer ratio. Nine kinds of DHBG with different glycopolymers and PEG lengths were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The aggregation capability of DHBG was investigated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). In all cases, the DHBGs formed the spherical structures, even when the PEG and glycopolymer lengths were quite different. The size of the structure was controlled by the ratio of the PEG length to the glycopolymer length. The aggregation of the DHBGs was induced by hydrogen bonding between the sugar moieties. The aggregation of the DHBG was affected by temperature and concentration.