The role of autophagy in vascular biology.
The role of autophagy in vascular biology.
复制标题
DOI：
10.1161/circresaha.116.303805
复制
发表时间：
2015-01-30
影响因子：
20.1
通讯作者：
Finkel T
中科院分区：
文献类型：
--
作者：
Nussenzweig SC;Verma S;Finkel T
自噬通量在维持正常血管壁生物学中的作用越来越受到关注，并且越来越怀疑自噬失调可能是血管老化和相关病理发展的常见途径。在内皮细胞和平滑肌细胞内，从氧化脂质到β-淀粉样蛋白的多种但重要的触发物似乎有力地刺激自噬体形成。此外，新出现的证据将自噬与从血管生成到血管壁钙化的各种血管过程联系起来。自噬通量的改变也越来越多地与包括动脉粥样硬化和肺动脉高压在内的疾病过程有关。最后，最近的见解指向一个重要的作用，自噬的旁分泌调节血管活性物质从内皮细胞。在这里，我们回顾了在理解自噬如何有助于血管生物学和新兴的策略，以针对这一过程的治疗效益的进展。
There is increasing interest in the role of autophagic flux in maintaining normal vessel wall biology, as well as a growing suspicion that autophagic dysregulation may be a common pathway through which vascular aging and associated pathologies develop. Within endothelial and smooth muscle cells, diverse but important triggers that range from oxidized lipids to β-amyloid appear to potently stimulate autophagosome formation. In addition, emerging evidence links autophagy to a wide array of vascular processes ranging from angiogenesis to calcification of the vessel wall. Alterations in autophagic flux are also increasingly being implicated in disease processes that include both atherosclerosis and pulmonary hypertension. Finally, recent insights point towards an important role of autophagy in the paracrine regulation of vasoactive substances from the endothelium. Here, we review the progress in understanding how autophagy can contribute to vascular biology and the emerging strategies to target this process for therapeutic benefit.