Autotransporters and Their Role in the Virulence of Burkholderia pseudomallei and Burkholderia mallei.
Autotransporters and Their Role in the Virulence of Burkholderia pseudomallei and Burkholderia mallei.
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DOI：
10.3389/fmicb.2011.00151
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发表时间：
2011
影响因子：
5.2
通讯作者：
Galyov EE
中科院分区：
文献类型：
--
作者：
Lazar Adler NR;Stevens JM;Stevens MP;Galyov EE
假马利氏伯克氏菌和马利氏伯克氏菌是密切相关的革兰氏阴性菌，分别是类鼻疽病和腺炎的病原。自体转运蛋白（ATs）包括一个大而多样的分泌和外膜蛋白家族，包括毒力相关的入侵蛋白、粘附素、蛋白酶和肌动蛋白成核因子。假马利氏双歧杆菌K96243基因组包含11个预测at，其中8个与马利氏双歧杆菌ATCC 23344基因组同源。本文综述了假麦氏芽孢杆菌和麦氏芽孢杆菌的体外和体内研究的主要发现。迄今为止，预测的假马利氏杆菌和马氏杆菌的AT中最具特征的是BimA，这是一种预测的三聚体AT，介导基于动作蛋白的运动，在伯克霍尔德氏菌种之间的序列和作用方式不同。在剩下的8种预测的假假芽孢杆菌三聚体自转运蛋白中，其中5种也存在于假芽孢杆菌中，其中2种（BoaA和BoaB）与细菌粘附上皮细胞有关。一些预测的伯克氏菌ATs被人类体液和细胞介导的免疫识别，表明它们在感染期间表达，可能对诊断和疫苗介导的保护有用。进一步研究伯克霍尔德菌ATs的分泌方式和功能，有助于合理设计防治策略。
Burkholderia pseudomallei and Burkholderia mallei are closely related Gram-negative bacteria responsible for the infectious diseases melioidosis and glanders, respectively. Autotransporters (ATs) comprise a large and diverse family of secreted and outer membrane proteins that includes virulence-associated invasins, adhesins, proteases, and actin-nucleating factors. The B. pseudomallei K96243 genome contains 11 predicted ATs, eight of which share homologs in the B. mallei ATCC 23344 genome. This review distils key findings from in silico, in vitro, and in vivo studies on the ATs of B. pseudomallei and B. mallei. To date, the best characterized of the predicted ATs of B. pseudomallei and B. mallei is BimA, a predicted trimeric AT mediating actin-based motility which varies in sequence and mode of action between Burkholderia species. Of the remaining eight predicted B. pseudomallei trimeric autotransporters, five of which are also present in B. mallei, two (BoaA and BoaB), have been implicated in bacterial adhesion to epithelial cells. Several predicted Burkholderia ATs are recognized by human humoral and cell-mediated immunity, indicating that they are expressed during infection and may be useful for diagnosis and vaccine-mediated protection. Further studies on the mode of secretion and functions of Burkholderia ATs will facilitate the rational design of control strategies.
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