Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants”
Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants”
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HPV 疫苗接种后伴有慢性疲劳的体位性心动过速，是“佐剂诱发的自身免疫/自身炎症综合征”的一部分
DOI：
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发表时间：
2014
影响因子：
1.2
通讯作者：
Y. Shoenfeld
中科院分区：
文献类型：
--
作者：
L. Tomljenovic;S. Colafrancesco;C. Perricone;Y. Shoenfeld
我们报告的情况下，一个14岁的女孩谁开发的姿势直立性心动过速综合征（POTS）与慢性疲劳2个月后Gardasil疫苗接种。患者出现持续性头痛、头晕、复发性晕厥、运动协调性差、虚弱、疲乏、肌痛、麻木、心动过速、呼吸困难、视觉障碍、声音恐惧症、认知障碍、失眠、胃肠道紊乱和体重减轻20磅。精神病评估排除了她的症状是心理性的或与焦虑症有关的可能性。此外，患者ANA（1：1280）、狼疮抗凝剂和抗磷脂检测呈阳性。在临床检查，她提出青斑网状，并被诊断为雷诺综合征。该病例符合佐剂诱导的自身免疫/自身炎症综合征（ASIA）的标准。由于普遍推荐青少年接种人乳头瘤病毒疫苗，并且POTS经常导致长期残疾（如我们的患者），因此强烈建议对接种疫苗后出现相关主诉的患者进行彻底随访。
We report the case of a 14-year-old girl who developed postural orthostatic tachycardia syndrome (POTS) with chronic fatigue 2 months following Gardasil vaccination. The patient suffered from persistent headaches, dizziness, recurrent syncope, poor motor coordination, weakness, fatigue, myalgias, numbness, tachycardia, dyspnea, visual disturbances, phonophobia, cognitive impairment, insomnia, gastrointestinal disturbances, and a weight loss of 20 pounds. The psychiatric evaluation ruled out the possibility that her symptoms were psychogenic or related to anxiety disorders. Furthermore, the patient tested positive for ANA (1:1280), lupus anticoagulant, and antiphospholipid. On clinical examination she presented livedo reticularis and was diagnosed with Raynaud’s syndrome. This case fulfills the criteria for the autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA). Because human papillomavirus vaccination is universally recommended to teenagers and because POTS frequently results in long-term disabilities (as was the case in our patient), a thorough follow-up of patients who present with relevant complaints after vaccination is strongly recommended.
影响因子：
158.5
作者：
Arbuckle, MR;McClain, MT;Harley, JB
通讯作者：
Harley, JB
体位性直立性心动过速综合征：梅奥诊所的经验。
影响因子：
8.9
作者：
Thieben,MarkJ;Sandroni,Paola;Sletten,DavidM;Benrud-Larson,LisaM;Fealey,RobertD;Vernino,Steven;Lennon,VandaA;Shen,Win-Kuang;Low,PhillipA
通讯作者：
Low,PhillipA
直立不耐受的模式：直立性心动过速综合征和青少年慢性疲劳。
DOI：
10.1016/s0022-3476(99)70025-9
发表时间：
1999
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Stewart,JM;Gewitz,MH;Weldon,A;Munoz,J
通讯作者：
Munoz,J