Hypogonadism induced by a transplantable, prolactin-producing tumor in male rats: hormonal and morphological studies.
Hypogonadism induced by a transplantable, prolactin-producing tumor in male rats: hormonal and morphological studies.
复制标题
雄性大鼠中由可移植的、产生催乳素的肿瘤引起的性腺功能减退症：激素和形态学研究。
DOI：
10.1210/endo-95-4-991
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发表时间：
1974
期刊：
影响因子：
4.8
通讯作者：
Robert L. Rosenfield
中科院分区：
文献类型：
--
作者：
Victor S. Fang;Samuel Refetoff;Robert L. Rosenfield
起源于 GH1B1 和 GH12C1 细胞克隆株的垂体肿瘤的主要区别在于催乳素产生的数量。将这些肿瘤移植到Wistar-Furth近交系大鼠体内后，只有携带大量催乳素和生长激素的GH1B1肿瘤的雄性大鼠表现出生长迟缓和生殖器萎缩。携带同一株 GH1B1 肿瘤的雌性大鼠和携带主要产生生长激素的 GH12C1 肿瘤的雄性大鼠没有受到类似的影响。与对照和 GH12C1 荷瘤动物相比，患有 GH,B! 的雄性大鼠肿瘤的循环催乳素水平显着升高，雌激素和黄体生成素水平适度升高，但睾酮水平极低。对 GH1B1 荷瘤大鼠萎缩睾丸和副性腺的组织学研究证实了这些动物中发现的雄激素低下症。激素数据强烈表明，源自肿瘤来源的高催乳素血症是导致……
Pituitary tumors originating from clonal strains of GH1B1 and GH12C1 cells differ mainly in the quantities of prolactin production. After these tumors were transplanted to Wistar- Furth inbred rats, only the male rats bearing GH1B1tumors which secreted high amount of prolactinand growth hormone exhibited growth retardation and genital atrophy. Female rats bearing the same strain of GH1B1 tumor and male rats bearing the predominantly growth hormone-producing GH12C1 tumor were not similarly affected. As compared to the control and GH12C1 tumorbearing animals, the male rats with GH,B! tumors had strikingly higher levels of circulating prolactin, moderately elevated levels of estrogen and luteinizing hormone but extremely low levels of testosterone. Histological studies of the atrophic testes and accessory sexual glands of the GH1B1 tumorbearing rats confirmed the hypoandrogenism foundin these animals. The hormonal data strongly suggest that hyperprolactinemia derived from tumor source was responsible for the...