AEROSOL TRANSMISSION OF RHINOVIRUS COLDS
AEROSOL TRANSMISSION OF RHINOVIRUS COLDS
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DOI：
10.1093/infdis/156.3.442
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发表时间：
1987-09-01
影响因子：
6.4
通讯作者：
INHORN, SL
中科院分区：
文献类型：
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作者：
DICK, EC;JENNINGS, LC;INHORN, SL
鼻病毒感染可通过气溶胶、直接接触或涉及环境物体的间接接触传播。我们研究了鼻病毒16型感冒在实验室感染的男性（捐赠者）和易感男性之间的传播中的气溶胶和间接接触在三个实验中，受限制的受试者的感染率分别为（10 [56%]的18），谁不能触摸他们的脸，只能被气溶胶感染，和无限制的收件人（18人中的12人[67%]），可能通过气溶胶、直接接触或间接污染物接触感染，没有显著差异（χ 2 = 0.468，P = 0.494）。在第四个实验中，通过8名捐赠者大量使用12小时的污染物传播是唯一可能的传播途径，在12名接受者中没有发生传播（通过双尾Fisher精确检验，P <0.001）。这些结果表明，与目前的观点相反，鼻病毒传播，至少在成人中，主要是通过气溶胶途径发生的。
Rhinovirus infections may spread by aerosol, direct contact, or indirect contact involving environmental objects. We examined aerosol and indirect contact in transmission of rhinovirus type 16 colds between laboratory-infected men (donors) and susceptible men (recipients) who played cards together for 12 hr. In three experiments the infection rate of restrained recipients (10 [56%] of 18), who could not touch their faces and could only have been infected by aerosols, and that of unrestrained recipients (12 [67%] of 18), who could have been infected by aerosol, by direct contact, or by indirect fomite contact, was not significantly different (.chi.2 = 0.468, P = .494). In a fourth experiment, transmission via fomites heavily used for 12 hr by eight donors was the only possible route of spread, and no transmissions occurred among 12 recipients (P < .001 by two-tailed Fisher''s exact test). These results suggest that contrary to current opinion, rhinovirus transmission, at least in adults, occurs chiefly by the aerosol route.