Evaluation of the Effects of Nicorandil on Experimentally Induced Gastric Ulcers
Evaluation of the Effects of Nicorandil on Experimentally Induced Gastric Ulcers
复制标题
尼可地尔对实验性胃溃疡的疗效评价
作者：
Hetal Patel;D. Santani;S. Goswami
本研究旨在评价钾通道开放剂尼可地尔在阿司匹林加幽门结扎诱导和乙醇诱导的大鼠胃溃疡中的作用，并阐明其可能的作用机制。为了确定KATP通道参与胃溃疡的调节，研究了尼可地尔单独给药以及与KATP通道阻滞剂格列本脲联合给药的作用。在整个研究期间，尼可地尔和格列本脲以2 mg/kg的剂量经口给药。尼可地尔在所有选定的模型中均显示出显著的保护作用，这从溃疡指数的显著降低中可见一斑。在两种模型中，尼可地尔治疗的结果与西咪替丁治疗的结果相当。发现格列本脲可抑制尼可地尔的这种作用。此外，格列本脲在乙醇和阿司匹林加幽门结扎模型中显示出促溃疡潜力。在阿司匹林加幽门结扎模型中，尼可地尔显示总酸度、胃蛋白酶活性和蛋白质含量显著降低，粘蛋白活性显著升高。还研究了尼可地尔对胃粘膜血流量（GMBF）的影响。发现试验组的GMBF增加幅度大于对照组，表明尼可地尔可增强GMBF。格列本脲也逆转了尼可地尔的这种作用。根据我们的研究得出结论，尼可地尔在本研究所用模型中具有抗溃疡活性。这可能是由于KATP通道开放，抑制酸分泌，增强粘蛋白活性，并改善GMBF。
The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats. In an attempt to ascertain the involvement of KATP channels in the modulation of gastric ulcers, the effects of nicorandil alone as well as in the presence of the KATP channel blocker glibenclamide were studied. Nicorandil and glibenclamide were administered orally at a dose of 2 mg/kg throughout the study. Nicorandil showed significant protection in all the selected models that was evident from a significant reduction in the ulcer index. The results of nicorandil treatment were comparable with those of cimetidine treatment in both models. Glibenclamide was found to inhibit this effect of nicorandil. Further, glibenclamide showed proulcerogenic potential in ethanol and aspirin plus pylorus ligation models. In the aspirin plus pylorus ligation model, nicorandil showed a significant reduction in total acidity, pepsin activity, and protein content and a significant rise in mucin activity. The effect of nicorandil was also studied on gastric mucosal blood flow (GMBF). The GMBF was found to be more increased in the test group than in the control group, indicating enhancement of GMBF by nicorandil. Glibenclamide reversed this effect of nicorandil as well. It is concluded from our study that nicorandil possesses antiulcer activity in the models employed in the present study. This may be attributed to the opening of KATP channels, inhibition of acid secretion, enhancement of mucin activity, and improvement in GMBF.
分离的犬壁细胞的细胞外钙和胆碱能刺激。
DOI：
10.1172/jci110243
发表时间：
1981
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Soll,AH
通讯作者：
Soll,AH
影响因子：
29.4
作者：
SZABO, S;TRIER, JS;SCHNOOR, J
通讯作者：
SCHNOOR, J