New polyphenolic β-lactams with antioxidant activity
New polyphenolic β-lactams with antioxidant activity
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DOI：
10.1002/cbdv.200890077
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Sinisi, Riccardo
中科院分区：
文献类型：
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作者：
Cainelli, Gianfranco;Angeloni, Cristina;Sinisi, Riccardo
合成了一种新型的带有多酚侧链的4-亚烷基-β-内酰胺类化合物，并对其作为自由基清除剂进行了评价。我们进行了详细的体外抗氧化活性的研究与化学和生物测试的新β-内酰胺和相应的甲基多羟基苯甲酸酯。β-内酰胺类和苯甲酸甲酯的抗氧化活性用Briggs-Rauscher振荡反应、TEAC（Trolox（R）等效抗氧化能力）测定以及抑制成肌细胞H9 c2细胞上ROS（=活性氧物质）产生的能力来测量。对实验结果进行了机理分析，并与结构参数进行了相关性分析.
Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and of the corresponding methyl polyhydroxy benzoates. Antioxidant activity of beta-lactams and methyl benzoates was measured with the Briggs-Rauscher oscillating reaction, the TEAC (Trolox (R) Equivalent Antioxidant Capacity) assay, and as ability to inhibit ROS (= Reactive Oxygen Species) production on myoblast H9c2 cells. The results were discussed with regard to mechanism and correlated with structural parameters.