Design of tissue engineering scaffolds based on hyperbolic surfaces: Structural numerical evaluation
Design of tissue engineering scaffolds based on hyperbolic surfaces: Structural numerical evaluation
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DOI：
10.1016/j.medengphy.2014.05.006
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发表时间：
2014-08-01
影响因子：
2.2
通讯作者：
Bartolo, Paulo J.
中科院分区：
文献类型：
--
作者：
Almeida, Henrique A.;Bartolo, Paulo J.
组织工程学代表了一个新的领域，旨在开发生物替代品来恢复、维持或改善组织功能。在这种方法中，支架为组织再生提供临时的机械和血管支持，同时形成组织内生长。这些支架必须是生物相容的，可生物降解的，具有适当的孔隙率、孔结构和分布，以及具有表面和结构兼容性的最佳血管形成。研究了两种不同类型的三周期极小曲面Schwarz和Schoen的应用，以期设计出更好的高比表面积、高孔隙率和良好力学性能的仿生支架。通过有限元软件ABAQUS对这些结构的力学性能进行了评估。还对两个参数(厚度和表面半径)对其孔隙率和力学行为的影响进行了评估。(C)2014年IPEM。爱思唯尔有限公司出版。保留所有权利。
Tissue engineering represents anew field aiming at developing biological substitutes to restore, maintain, or improve tissue functions. In this approach, scaffolds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and distribution, and optimal vascularization with both surface and structural compatibility. The challenge is to establish a proper balance between porosity and mechanical performance of scaffolds.This work investigates the use of two different types of triple periodic minimal surfaces, Schwarz and Schoen, in order to design better biomimetic scaffolds with high surface-to-volume ratio, high porosity and good mechanical properties. The mechanical behaviour of these structures is assessed through the finite element method software Abaqus. The effect of two parametric parameters (thickness and surface radius) is also evaluated regarding its porosity and mechanical behaviour. (C) 2014 IPEM. Published by Elsevier Ltd. All rights reserved.