Potential effects of chondroitin sulfate on joint swelling: a GAIT report.
Potential effects of chondroitin sulfate on joint swelling: a GAIT report.
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DOI：
10.1016/j.joca.2008.06.024
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发表时间：
2008
影响因子：
7
通讯作者：
Clegg DO
中科院分区：
文献类型：
--
作者：
Hochberg MC;Clegg DO
氨基葡萄糖/软骨素关节炎干预试验（GAIT）是一项随机双盲安慰剂和活性对照药物（塞来昔布）对照试验，纳入了1583名膝关节症状性骨关节炎（OA）患者1。与随机分配至安慰剂组的患者相比，随机分配至塞来昔布组的患者膝关节疼痛显著改善。与安慰剂相比，随机分配至膳食补充剂组的患者膝关节疼痛没有统计学显著改善，尽管一部分在入组时患有中度至重度膝关节疼痛的患者被分配至葡萄糖胺和硫酸软骨素的组合似乎确实经历了一些改善。此外，注意到服用硫酸软骨素的患者膝关节肿胀有统计学显著改善。GAIT患者的探索性事后分析表明，硫酸软骨素对关节肿胀的影响更常发生在入组时疼痛较轻和Kelling-Lawrence分级较低的患者中。
The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) was a randomized double-blind placebo and active comparator (celecoxib) controlled trial of 1583 persons with symptomatic osteoarthritis (OA) of the knee1. Patients randomized to celecoxib had significant improvement in knee pain compared to those randomized to placebo. No statistically significant improvement in knee pain compared to placebo was seen among patients randomized to the dietary supplements, although a subset of patients with moderate-to-severe knee pain at entry who were assigned to the combination of glucosamine and chondroitin sulfate did seem to experience some improvement. Additionally, patients taking chondroitin sulfate were noted to have a statistically significant improvement in knee joint swelling. An exploratory post hoc analysis of GAIT patients suggested the effect of chondroitin sulfate on joint swelling occurred more often in patients with milder pain and lower Kellgren–Lawrence Grade at entry.
影响因子：
158.5
作者：
Clegg, DO;Reda, DJ;Williams, HJ
通讯作者：
Williams, HJ
DOI：
10.1331/154434506775268616
发表时间：
2006-01-01
影响因子：
2.1
作者：
Barnhill, Jamie G.;Fye, Carol L.;Clegg, Daniel O.
通讯作者：
Clegg, Daniel O.
影响因子：
7
作者：
Pham, T;van der Heijde, D;Dougados, M
通讯作者：
Dougados, M