Quantitative pretreatment EEG predicts efficacy of ACTH therapy in infantile epileptic spasms syndrome
Quantitative pretreatment EEG predicts efficacy of ACTH therapy in infantile epileptic spasms syndrome
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DOI：
10.1016/j.clinph.2022.10.004
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发表时间：
2022-10-27
影响因子：
4.7
通讯作者：
Maegaki, Yoshihiro
中科院分区：
文献类型：
--
作者：
Kanai, Sotaro;Oguri, Masayoshi;Maegaki, Yoshihiro
目的：探讨促肾上腺皮质激素（ACTH）治疗与非病变性婴儿癫痫痉挛综合征（IESS）前处理脑电图（EEG）的相对功率谱（rPS）、加权相位滞后指数（wPLI）和图理论分析的相关性。方法：选取28例非病变性IESS患者。根据ACTH治疗后癫痫复发情况分为无发作组（F, n = 21）和癫痫复发组（R, n = 7）。计算预处理脑电图的rPS、wPLI、聚类系数、中间中心性，并进行统计学分析，确定其与ACTH治疗后预后的相关性。结果：R组δ频带rPS值显著高于F组（p < 0.001）。R组δ、θ、α频带wPLI值显著高于F组（p = 0.007）；
Objective: This study aimed to determine the correlation between outcomes following adrenocorti-cotrophic hormone (ACTH) therapy and measurements of relative power spectrum (rPS), weighted phase lag index (wPLI), and graph theoretical analysis on pretreatment electroencephalography (EEG) in infants with non-lesional infantile epileptic spasms syndrome (IESS).Methods: Twenty-eight patients with non-lesional IESS were enrolled. Outcomes were classified based on seizure recurrence following ACTH therapy: seizure-free (F, n = 21) and seizure-recurrence (R, n = 7) groups. The rPS, wPLI, clustering coefficient, and betweenness centrality were calculated on pretreatment EEG and were statistically analyzed to determine the correlation with outcomes following ACTH therapy.Results: The rPS value was significantly higher in the delta frequency band in group R than in group F (p < 0.001). The wPLI values were significantly higher in the delta, theta, and alpha frequency bands in group R than in group F (p = 0.007,