EFFECT OF E TYPE PROSTAGLANDINS ON PROLIFERATION OF HEMATOPOIETIC STEM-CELLS INVIVO
EFFECT OF E TYPE PROSTAGLANDINS ON PROLIFERATION OF HEMATOPOIETIC STEM-CELLS INVIVO
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DOI：
10.1111/j.1365-2184.1977.tb00304.x
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
FEHER, I
中科院分区：
文献类型：
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作者：
GIDALI, J;FEHER, I
在体内研究了前列腺素 E1 和 E2 刺激造血干细胞 (CFU) [小鼠] 增殖的能力。剂量范围为10-4-10-1μg/g体重的PGE2和剂量范围为10-5-10-1μg/g体重的PGE1产生了CFU的快速循环波。 S期CFU数量的增加并没有伴随股骨CFU含量的增加，并且除了股骨CFUc水平短暂增加之外，没有发现分化增加。 PG诱导的CFU刺激后的造血显然是无效的。 PGE2 不会刺激处于扰动状态（亚致死照射后）的 CFU 再生。所有这些发现都支持这样的观点，即 PGE 可能代表生理剂量下作用的造血干细胞的有效刺激剂。如果与生理控制系统同时作用，PG 会导致无效的造血（在正常条件下）或不发挥任何可测量的作用（亚致死照射后）。
The ability of prostaglandins E1 and E2 to stimulate the proliferation of hemopoietic stem cells (CFUs) [mouse] was studied in vivo. PGE2, in a dose range of 10-4-10-1 .mu.g/g body weight and PGE1 in a dose range of 10-5-10-1 .mu.g/g body weight, produced a rapid cycling wave of CFUs. The increase in the number of CFUs in S phase was not followed by a rise in the femoral CFUs content, and except for a transient increase in femoral CFUc level, no increase in differentiation was found. Hemopoiesis after PG-induced CFU stimulation apparently is ineffective. PGE2 did not stimulate regeneration of CFUs in a perturbed state (after sublethal irradiation). All these findings support the idea that PGE might represent potent stimulators of the hemopoietic stem cells acting in physiological doses. If acting concurrently with physiological control systems PG lead to ineffective hemopoiesis (under normal conditions) or do not exert any measurable effect (after sublethal irradiation).