Ror receptor tyrosine kinases: orphans no more.
Ror receptor tyrosine kinases: orphans no more.
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DOI：
10.1016/j.tcb.2008.08.006
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发表时间：
2008-11
影响因子：
19
通讯作者：
Sternberg PW
中科院分区：
文献类型：
--
作者：
Green JL;Kuntz SG;Sternberg PW
Ror蛋白是一个保守的酪氨酸激酶受体家族，在发育过程中起作用，包括骨骼和神经元发育、细胞运动和细胞极性。虽然Ror（受体酪氨酸激酶样孤儿受体）蛋白最初被命名是因为相关的配体和信号通路未知，但最近在多种物种中的研究现在确定Ror蛋白是Wnt受体。根据细胞环境，Ror蛋白可以激活或抑制Wnt靶基因的转录，并可以通过隔离Wnt配体来调节Wnt信号传导。新的证据表明Ror蛋白参与平面细胞极性（PCP），这是Wnt的另一种途径。在这里，我们回顾了在理解这些神秘蛋白方面取得的进展，特别是我们重点关注它们作为Wnt受体的功能。
Ror proteins are a conserved family of tyrosine kinase receptors that function in developmental processes, including skeletal and neuronal development, cell movement, and cell polarity. While Ror (receptor tyrosine kinase-like orphan receptor) proteins were originally named because the associated ligand and signaling pathway were unknown, recent studies in multiple species now establish that Ror proteins are Wnt receptors. Depending on the cellular context, Ror proteins can either activate or repress transcription of Wnt target genes and can modulate Wnt signaling by sequestering Wnt ligands. New evidence implicates Ror proteins in planar cell polarity (PCP), an alternative Wnt pathway. Here, we review the progress made in understanding these mysterious proteins and in particular we focus on their function as Wnt receptors.