SYNTHESIS OF SOME 5-ALKYL-6-AZAURACILS
SYNTHESIS OF SOME 5-ALKYL-6-AZAURACILS
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DOI：
10.1021/jo01106a038
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发表时间：
1958-01-01
影响因子：
3.6
通讯作者：
CHANG, PK
中科院分区：
文献类型：
--
作者：
CHANG, PK
在非水介质中，在乙氧基钠的存在下，通过适当的酮酸缩氨基脲封环，合成了一系列5-烷基-6-氮化脲（6-烷基-ast/m-三嗪- 3,5 -二酮）。与6-杜鹃花酸相比，这些化合物对小鼠的麻醉活性增加，旨在帮助研究将麻醉与6-杜鹃花酸的抗肿瘤活性分离。测定了它们的酸解常数、紫外光谱和红外光谱。
A number of 5-alkyl-6-azauracils (6-alkyl-ast/m-triazine-3, 5-diones) have been synthesized by ring closure of the appropriate-keto acid semicarbazones in non-aqueous mediain the presence of sodium ethoxide. As compared to 6-azauracil, these compounds show increased narcotic activity in mice, and were designed to aidin studies dissociating the narcotic from the anti-tumor activities of 6-azauracil. Their acid dissociation constants, ultraviolet spectra, andinfrared spectra were measured.