Infection of lung epithelial cells and induction of pulmonary adenocarcinoma is not the most common outcome of naturally occurring JSRV infection during the commercial lifespan of sheep
Infection of lung epithelial cells and induction of pulmonary adenocarcinoma is not the most common outcome of naturally occurring JSRV infection during the commercial lifespan of sheep
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DOI：
10.1016/j.virol.2005.05.018
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发表时间：
2005-07-20
期刊：
影响因子：
3.7
通讯作者：
Palmarini, M
中科院分区：
文献类型：
--
作者：
Caporale, M;Centorame, P;Palmarini, M
绵羊肺腺瘤病毒（Jaagsiekte sheep retrovirus，JSRV）是绵羊肺腺癌（ovine pulmonary adenocarcinoma，OPA）的病原体。在这项研究中，我们在31个月的时间内，在成年羊和他们的后代的自然传播JSRV。我们建立了来自OPA发病率高或低的鸡群的组，并在尸检时监测病毒传播、临床疾病和肉眼/显微镜肺部病变。获得的结果表明：（i）JSRV感染可发生在围产期或羔羊和成年绵羊生命的最初几个月;（ii）只有少数JSRV感染动物在其商业寿命期间发生临床疾病;（iii）JSRV在外周血白细胞和淋巴器官中比在肺中更容易检测到。这些数据支持一个模型的机会性JSRV感染和致瘤转化的II型肺细胞/克拉拉细胞在肺，而淋巴网状细胞作为主要的病毒水库。(C)2005年爱思唯尔公司All rights reserved.
Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA). In this study, we followed over a 31-month period the natural transmission of JSRV in adult sheep and in their offspring. We established groups derived from flocks with either a high or low incidence of OPA and monitored virus transmission, clinical disease and macroscopic/microscopic lung lesions at necropsy. Results obtained show that (i) JSRV infection can occur perinatally or in the first few months of life in lambs and in adult sheep; (ii) only a minority of JSRV-infected animals develop clinical disease during their commercial lifespan; and (iii) JSRV is more readily detectable in peripheral blood leucocytes and lymphoid organs than in the lungs. These data support a model of opportunistic JSRV infection and tumorigenic conversion of type II pneumocytes/Clara cells in the lungs, while lymphoreticular cells serve as the principal virus reservoir. (C) 2005 Elsevier Inc. All rights reserved.