EFFECTS OF EXPOSURE TO PCBS AND RELATED-COMPOUNDS ON GROWTH AND ACTIVITY IN CHILDREN
EFFECTS OF EXPOSURE TO PCBS AND RELATED-COMPOUNDS ON GROWTH AND ACTIVITY IN CHILDREN
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DOI：
10.1016/0892-0362(90)90050-m
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发表时间：
1990-07-01
影响因子：
2.9
通讯作者：
HUMPHREY, HEB
中科院分区：
文献类型：
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作者：
JACOBSON, JL;JACOBSON, SW;HUMPHREY, HEB
二百三十六名儿童从两个既定的chorts在风险暴露于多氯联苯（PCB）和相关污染物进行了评估，在4岁。产前暴露（通过脐带血清多氯联苯水平评估）与较低的体重有关，这种影响与台湾高水平暴露的实验室大鼠和儿童以及日本一般人群中生长迟缓的报告一致。接触最多的儿童比接触最少的儿童平均轻1.8公斤。根据儿童母亲和两名独立检查员提供的综合评分，当代身体负担（通过4年血清PCB水平评估）与活动减少有关。这种影响归因于哺乳期接触，在母乳中PCB水平高于平均水平且母乳喂养至少1年的妇女的后代中最强。虽然体重不足是与以往的数据相一致的低剂量的人类接触多氯联苯的发育影响，特别是在产前时期，活动是第一个领域被发现受到影响的哺乳期在当代水平的曝光。
Two hundred thirty-six children from two established chorts at risk for exposure to polychlorinated biphenyls (PCBs) and related contaminants were evaluated at age 4 years. Prenatal exposure (assessed by cord serum PCB level) was associated with lower weight, an effect consistent with reports of growth retardation in laboratory rats and in children exposed at high levels in Taiwan and at general population levels in Japan. The highest exposed children weighed 1.8 kg less on the average than the least exposed. Contemporary body burden (assessed by 4-year serum PCB level) was associated with reduced activity based on composite ratings provided by the child''s mother and two independent examiners. This effect attributable to lactation exposure, was strongest among the offspring of women with above average milk PCB levels who breast fed for at least 1 year. While the weight deficit is consistent with previous data linking developmental effects of low-dose human PCB exposures specifically to the prenatal period, activity is the first domain found to be affected by lactation at contemporary levels of exposure.