Renin-angiotensin and sympathetic nervous system activity in grade school children.
Renin-angiotensin and sympathetic nervous system activity in grade school children.
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小学生的肾素-血管紧张素和交感神经系统活动。
DOI：
10.1161/01.hyp.4.2.299
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Prineas,RJ
中科院分区：
文献类型：
--
作者：
Sinaiko,AR;Gillum,RF;JacobsJr,DR;Sopko,G;Prineas,RJ
对从明尼阿波利斯公立学校调查中构建的血压分布的上 0.26% 和下 5% 中选出的小学生进行了肾素-血管紧张素和交感神经系统活动的评估。来自较高 0.26% 组的 11 名儿童和来自较低 5% 组的 19 名儿童被送入临床研究中心 5 天，并维持 110 mEq 钠和 75 mEq 钾饮食。住院第五天，在仰卧位、直立姿势 2 小时后以及跑步机锻炼后采集血样。两组之间的平均钠和钾排泄以及血清钠和钾相似。在三个采样时间的任何一个时间，两组之间的血浆去甲肾上腺素没有显着差异。在仰卧和 2 小时直立样本中，0.26% 组的血浆肾素活性明显较低。平均血浆醛固酮（仅在仰卧位血液样本中测量）在各组之间没有显着差异。仅在较低 5% 组中，血浆醛固酮值与血浆肾素活性显着相关（r = 0.67，p < 0.005）。这项研究表明，小学儿童中高血压和低血压儿童的交感神经系统活动相似，但血浆肾素活性较低，并且高血压组血浆醛固酮和肾素活性之间存在明显的分离。这些发现应该在从整个血压分布中选择大量受试者的研究中得到证实。（Hypertension 4: 299-306, 1982）
Renin-angiotensin and sympathetic nervous system activity were evaluated in grade school children selected from the upper 0.26% and lower 5% of the blood pressure distribution constructed from a survey in the Minneapolis Public Schools. Eleven children from the upper 0.26% group and 19 children from the lower 5% group were admitted to the Clinical Research Center for 5 days and maintained on a 110 mEq sodium and 75 mEq potassium diet. On the fifth hospital day blood samples were obtained supine, after 2 hours of upright posture and after treadmill exercise. Mean sodium and potassium excretion and serum sodium and potassium were similar between the two groups. Plasma norepinephrine was not significantly different between the two groups at any of the three sampling times. Plasma renin activity was significantly lower in the upper 0.26% group in the supine and 2-hour upright samples. Mean plasma aldosterone (measured only in the supine blood samples) was not significantly different between groups. Plasma aldosterone values were significantly correlated with plasma renin activity only in the lower 5% group (r= 0.67, p< 0.005). This study suggests that in grade school children sympathetic nervous system activity is similar between children with high and low blood pressure but that plasma renin activity is lower and an apparent dissociation between plasma aldosterone and renin activity exists in the high blood pressure group. These findings should be confirmed in studies with larger numbers of subjects selected from the entire distribution of blood pressure.(Hypertension 4: 299-306, 1982)