Quantifying the Nonlinear Interaction in the Nervous System Based on Phase-Locked Amplitude Relationship.
Quantifying the Nonlinear Interaction in the Nervous System Based on Phase-Locked Amplitude Relationship.
复制标题
基于锁相幅度关系量化神经系统中的非线性相互作用。
DOI：
10.1109/tbme.2020.2967079
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Schouten,AlfredC
中科院分区：
文献类型：
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作者：
Yang,Yuan;Yao,Jun;Dewald,JuliusPA;vanderHelm,FransCT;Schouten,AlfredC
目的本文介绍了跨频幅度传递函数（CATF），这是一种基于锁相幅度关系量化非线性刺激-响应相互作用的无模型方法。方法CATF估计从刺激信号的输入频率到响应信号的谐波/互调的幅度传递。我们首先在包含静态非线性函数和线性动态的系统（即 Hammerstein 和 Wiener 系统）的模拟测试中验证了 CATF 的性能。然后我们应用CATF来研究人类本体感觉系统中从外周到皮层的二阶非线性幅度传递。结果仿真表明CATF是一种通用方法，可以很好地量化Wiener或Hammerstein系统配置中不同阶非线性的非线性刺激-响应幅度传递。应用于人类本体感觉系统，我们发现了一种复杂的非线性系统行为，其从外围刺激到α波段皮质响应信号的大幅度转移。这种复杂的系统行为可能与肌梭的非线性行为和丘脑皮质辐射中的动态相互作用有关。结论本文提供了一种识别神经系统中非线性相互作用的新工具。意义该结果为人类本体感觉系统中的非线性动力学提供了新的见解。
ObjectiveThis paper introduces the Cross-frequency Amplitude Transfer Function (CATF), a model-free method for quantifying nonlinear stimulus-response interaction based on phase-locked amplitude relationship.MethodThe CATF estimates the amplitude transfer from input frequencies at stimulation signal to their harmonics/intermodulation at the response signal. We first verified the performance of CATF in simulation tests with systems containing a static nonlinear function and a linear dynamic, i.e., Hammerstein and Wiener systems. We then applied the CATF to investigate the second-order nonlinear amplitude transfer in the human proprioceptive system from the periphery to the cortex.ResultThe simulation demonstrated that the CATF is a general method, which can well quantify nonlinear stimulus-response amplitude transfer for different orders of nonlinearity in Wiener or Hammerstein system configurations. Applied to the human proprioceptive system, we found a complicated nonlinear system behavior with substantial amplitude transfer from the periphery stimulation to cortical response signals in the alpha band. This complicated system behavior may be associated with the nonlinear behavior of the muscle spindle and the dynamic interaction in the thalamocortical radiation.ConclusionThis paper provides a new tool to identify nonlinear interaction in the nervous system.SignificanceThe results provide novel insight of nonlinear dynamics in the human proprioceptive system.