The fast degradation of β-TCP ceramics facilitates healing of bone defects by the combination of BMP-2 and Teriparatide
The fast degradation of β-TCP ceramics facilitates healing of bone defects by the combination of BMP-2 and Teriparatide
复制标题
β-TCP 陶瓷的快速降解通过 BMP-2 和特立帕肽的组合促进骨缺损的愈合
DOI：
10.1016/j.biopha.2019.01.039
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发表时间：
2019-04-01
影响因子：
7.5
通讯作者：
Yang, Lei
中科院分区：
文献类型：
--
作者：
Xie, Zhongjie;Yan, Deyi;Yang, Lei
Accumulating evidence suggests that the degradation and resorption of calcium phosphate ceramics is always relatively slow, which may inhibit calcium phosphate ceramics' replacement by new bone tissues and the ultimate bone defect repair. Bone morphogenetic proteins (BMPs) and Teriparatide (PTH) are extensively applied in the treatment of bone pathologies, while their effects on the degradation of calcium phosphate ceramics is limited. In this study, we tested the effects of BMP and PTH on degradation of beta-tricalcium phosphate (beta-TCP) ceramics and bone formation on beta-TCP in ovariectomized (OVX) rat models. After establishment of femur defect model on OVX rats, the BMP + PTH group's rats were injected Teriparatide (30 mu g/kg) subcutaneous every other day, while rats of control group and group BMP were injected equal-to-group volume sterilized saline water. Twelve weeks after femur surgery, all rats were sacrificed for Micro-CT scanning and histology tests. The results showed that BMP facilitated degradation of beta-TCP and new bone formation on beta-TCP ceramics. And PTH showed an additional effect on degradation of beta-TCP when combined with BMP. In addition, the results explained that PTH promoted the remodeling of the bone callus occurred during repair.
