Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives
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DOI：
10.1016/s0166-2236(99)01399-5
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发表时间：
1999-09
影响因子：
15.9
通讯作者：
R. Rupprecht;F. Holsboer
中科院分区：
文献类型：
--
作者：
R. Rupprecht;F. Holsboer
类固醇通过与细胞内受体结合来影响神经元功能，细胞内受体可以作为转录因子并调节基因表达。此外，一些所谓的“神经活性类固醇”是一系列配体门控离子通道和不同的G蛋白偶联受体通过非基因组机制的有效调节剂，它们可以影响睡眠和记忆。本文介绍了这些神经活性类固醇如何调节神经递质受体，并解决了神经精神药理学的潜力，从基因组和非基因组类固醇效应之间的细胞内串扰。神经活性类固醇还可以在应对压力和治疗精神疾病（如抑郁症）方面发挥作用，并且由于它们通过其独特的分子特性影响广泛的行为功能，因此它们可能构成尚未开发的一类药物。
Steroids influence neuronal function by binding to intracellular receptors that can act as transcription factors and regulate gene expression. In addition, some so-called ‘neuroactive steroids' are potent modulators of an array of ligand-gated ion channels and of distinct G-protein coupled receptors via nongenomic mechanisms, and they can influence sleep and memory. This article describes how these neuroactive steroids modulate neurotransmitter receptors and addresses the neuropsychopharmacological potential that arises from the intracellular crosstalk between genomic and nongenomic steroid effects. Neuroactive steroids could also have a role in the response to stress and the treatment of psychiatric disorders, such as depression, and, as they affect a broad spectrum of behavioral functions through their unique molecular properties, they could constitute a yet unexploited class of drugs.