Pseudotannins self-assembled into antioxidant complexes
Pseudotannins self-assembled into antioxidant complexes
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DOI：
10.1039/c5sm01224d
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发表时间：
2015-01-01
期刊：
影响因子：
3.4
通讯作者：
Fisher, O. Z.
中科院分区：
文献类型：
--
作者：
Cheng, H. A.;Drinnan, C. T.;Fisher, O. Z.
天然单宁因其抗氧化性能和与其他大分子形成聚合物间络合物(IPC)的能力而被用作生物材料的构建块。单宁在生物医学应用中的主要挑战之一是其在生理条件下的不稳定性以及缺乏对纯度和反应活性的控制。在此，我们报道了具有可控结构、反应活性和大小的类单宁聚合物的合成和表征。这些假单宁是通过用没食子酸基、间苯二环基团和原儿茶酸侧基取代直链葡聚糖链来模拟天然可水解性单宁的结构来合成的。我们证明了这些新材料可以自组装形成还原和胶体稳定的纳米和微米级粒子。具体地说，评价了由伪单宁和聚乙二醇制得的IPC的合成、浊度、颗粒大小、抗氧化能力和细胞摄取。
Natural tannins are attractive as building blocks for biomaterials due to their antioxidant properties and ability to form interpolymer complexes (IPCs) with other macromolecules. One of the major challenges to tannin usage in biomedical applications is their instability at physiological conditions and a lack of control over the purity and reactivity. Herein, we report the synthesis and characterization of tannin-like polymers with controlled architecture, reactivity, and size. These pseudotannins were synthesized by substituting linear dextran chains with gallic, resorcylic, and protocatechuic pendant groups to mimic the structure of natural hydrolysable tannins. We demonstrate that these novel materials can self-assemble to form reductive and colloidally stable nanoscale and microscale particles. Specifically, the synthesis, turbidity, particle size, antioxidant power, and cell uptake of IPCs derived from pseudotannins and poly(ethylene glycol) was evaluated.