An Enyne Cycloisomerization Approach to the Triple Reuptake Inhibitor GSK1360707F
An Enyne Cycloisomerization Approach to the Triple Reuptake Inhibitor GSK1360707F
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DOI：
10.1021/jo102098y
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发表时间：
2011-01-21
影响因子：
3.6
通讯作者：
Tabet, Elie A.
中科院分区：
文献类型：
--
作者：
Deschamps, Nicole M.;Elitzin, Vassil I.;Tabet, Elie A.
通过铂（II）或金(I)催化的环异构化反应，合成了三重再摄取抑制剂GSK1360707F。讨论了本工作的关键方面，如氮保护基团的选择和初始的正抗选择性研究。
The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by either Pt(II) or Au(I). Key aspects of this work such as the choice of the nitrogen protecting group and initial en-antioselectivity studies are discussed.