The growing teratoma syndrome:: results of therapy and long-term follow-up of 33 patients
The growing teratoma syndrome:: results of therapy and long-term follow-up of 33 patients
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DOI：
10.1016/s0959-8049(00)00137-4
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发表时间：
2000-07-01
影响因子：
8.4
通讯作者：
Théodore, C
中科院分区：
文献类型：
--
作者：
André, F;Fizazi, K;Théodore, C
畸胎瘤生长综合征（GTS）被定义为生殖细胞肿瘤（GCT）化疗期间或化疗后肿瘤尺寸增加，并且在切除的肿瘤标本的组织学分析中仅发现成熟畸胎瘤。 1985 年至 1997 年间，本研究纳入了 30 名符合 GTS 标准的男性患者。还包括 3 名女性患者，但单独分析。在 86% 的原发性 GCT 中发现了成熟畸胎瘤成分。 3 名男性患者 (10%) 在诊断 GTS 时出现并发症。一名接受完全切除的男性患者 (4%) (n = 24) 出现复发性 GTS，而除 1 名接受部分切除的患者 (83%) 之外的所有患者 (n = 6) 则出现复发性 GTS (P < 0.001)。 2 名（8%）和 3 名（50%）接受完全切除和部分切除治疗的男性患者随后分别发展为恶性 NSGCT（P = 0.01）。 2 名接受部分切除治疗的女性患者出现复发性 GTS。其中一人死于这种复发性 CTS。就并发症和疾病的自然史而言，GTS 本身就是一个实体。完全手术切除是 GTS 的首选治疗方法。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
Growing teratoma syndrome (GTS) is defined as an increase in tumour size during or after chemotherapy for germ cell tumour (GCT), and only mature teratoma at histological analysis of the resected tumour specimen. Between 1985 and 1997, 30 male patients fulfilling GTS criteria were included in the present study. 3 female patients were also included but analysed separately. A mature teratoma component was found in 86% of the primary GCT. 3 male patients (10%) had a complication at diagnosis of GTS. One male patient (4%) having undergone complete resection (n = 24) had a recurrent GTS, compared with all but 1 patient (83%) in whom resection was partial (n = 6) (P < 0.001). 2 (8%) and 3 (50%) male patients treated with complete and partial resection subsequently developed a malignant NSGCT respectively (P = 0.01). 2 female patients treated with partial resection presented a recurrent GTS. One of them died of this recurrent CTS. GTS is an entity in its own right with respect to complications and the natural history of the disease. Complete surgical resection is the treatment of choice for GTS. (C) 2000 Elsevier Science Ltd. All rights reserved.