Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice
Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice
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DOI：
10.1016/j.brainres.2007.02.077
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发表时间：
2007-05-30
期刊：
影响因子：
2.9
通讯作者：
Sei, Hiroyoshi
中科院分区：
文献类型：
--
作者：
Kitaoka, Kazuyoshi;Hattori, Atsushi;Sei, Hiroyoshi
最近的报告（Maret，S.，弗兰肯，P.，Dauvilliers，Y.，Ghyselinck，N.B.，尚邦山口，Tafti，M.，2005.视黄酸信号影响睡眠期间皮质的同步性。Science 310，111-113.）研究表明，维生素A（视黄醇及其衍生物）在遗传上与睡眠期间的脑电图（EEG）δ振荡有关。然而，这一发现尚未得到其他研究的证实。在这项研究中，我们试图记录睡眠脑电图和行为，并定量纹状体单胺在小鼠喂养维生素A缺乏（VAD）饮食4周，以澄清δ振荡和维生素A之间的联系。VAD小鼠表现出EEG的δ功率的显著降低。然而，6小时的睡眠剥夺导致VAD小鼠的δ功率恢复到与对照组相似的水平。VAD还引起24小时内自发活动减少。此外，二羟苯基乙酸，多巴胺的代谢产物，在VAD小鼠的纹状体组织显着减少。我们目前的研究结果表明，维生素A的缺乏会导致NREM睡眠和自发活动中δ功率的衰减。这些衰减可能与纹状体多巴胺能功能的改变有关。(c)2007 Elsevier B. V.保留所有权利。
Recent report (Maret, S., Franken, P., Dauvilliers, Y., Ghyselinck, N.B., Chambon, P., Tafti, M., 2005. Retinoic acid signaling affects cortical synchrony during sleep. Science 310, 111-113.) has suggested that vitamin A (retinol and its derivatives) is genetically involved in the electroencephalogram (EEG) delta oscillation during sleep. However, this finding has not yet been confirmed by other studies. In this study, we attempted to record the sleep EEG and behavior, and to quantify striatal monoamines in mice fed a vitamin A-deficient (VAD) diet for 4 weeks, in order to clarify the linkage between the delta oscillation and vitamin A. VAD mice demonstrated a significant decrease in the delta power of the EEG. However, 6-h sleep deprivation caused the recovery of the delta power in VAD mice to a level similar to that of the control. VAD also caused the decrease of spontaneous activity throughout 24-h period. Furthermore, dihydroxyphenyl acetic acid, a metabolite of dopamine, was decreased significantly in the striatal tissue of VAD mice. Our present results suggest that the deficiency of vitamin A causes the attenuation of delta power in NREM sleep and spontaneous activity. These attenuations may be related to the alteration of striatal dopaminergic function. (c) 2007 Elsevier B.V. All rights reserved.