Mortality in a Chinese chrysotile miner cohort
Mortality in a Chinese chrysotile miner cohort
复制标题
中国温石棉矿工群体的死亡率
DOI：
10.1007/s00420-011-0685-9
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Wang M
中科院分区：
文献类型：
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作者：
Wang X;Lin S;Yano E;Qiu H;Yu IT;Tse L;Lan Y;Wang M
研究背景中国石棉矿工死因特异性死亡率的数据很少。本研究观察了一个队列的工人从最大的温石棉矿石棉暴露和cause-specific mortality.MethodsThe队列包括1,539名男性工人之间的关联进行了评估，从1981年至2006年。通过个人记录和个人联系获得有关职业和吸烟史以及生命状况的信息。从医院核实了死亡原因和日期。工人分为两组：矿工和米莱尔（矿工组）和对照组（不直接接触）。最近在工作场所进行的石棉粉尘测量表明，浓度范围为12至197毫克/立方米。角闪石污染程度很低。采用具有竞争风险的考克斯比例风险模型来估计与石棉暴露相关的原因特异性死亡率的风险比（矿工与对照组）。此外，标准化死亡率（SMRs）计算的基础上，国家mortality rates.ResultsAll选定的原因，特别是肺癌的死亡率，矿工组比对照组高得多。矿工肺癌和非恶性呼吸道疾病的SMR分别为4.71（95% CI，3.57，6.21）和3.53（2.78，4.48）。对照组的所有原因、肺癌和所有癌症的死亡率与全国死亡率相似，但呼吸系统疾病的死亡率较高。在调整吸烟和年龄的同时，接触砷与肺癌的死亡风险增加4.6倍，与所有癌症和呼吸系统疾病的死亡风险增加3倍以上有关。肺癌的SMR最高的矿工who smoked.ConclusionThe结果表明过度的原因特异性死亡率，特别是肺癌和呼吸系统疾病，在队列中，这是与暴露于温石棉。
BackgroundFew data were available to address cause-specific mortality in asbestos miners in China. This study observed a cohort of workers from the largest chrysotile asbestos mine to evaluate the association between asbestos exposure and cause-specific mortality.MethodsThe cohort consisting of 1,539 male workers was observed from 1981 to 2006. Information on occupational and smoking history and vital status was obtained through personnel records and individual contact. Causes and dates of deaths were verified from hospitals. Workers were divided into two groups: miners and millers (miner group) and control group (not direct exposed). Recent asbestos dust measurements in the workplaces showed that the concentrations ranged from 12 to 197 mg/m3. Amphibole contamination was very low. Cox proportional hazard models with competing risks were fit to estimate hazard ratios for cause-specific mortality associated with asbestos exposure (miners vs. controls). In addition, standardized mortality ratios (SMRs) were calculated based on national mortality rates.ResultsAll mortality rates of selected causes, particularly lung cancer, were substantially higher in the miner group than in the controls. SMRs of lung cancer and nonmalignant respiratory diseases in the miners were 4.71 (95% CI, 3.57, 6.21) and 3.53 (2.78, 4.48), respectively. The controls had similar mortality rates of all causes, lung cancer, all cancers as national rates, but a higher mortality from respiratory diseases. Asbestos exposure was related to a 4.6-fold mortality risk for lung cancer and over threefold risk for all cancers and respiratory diseases, while smoking and age were adjusted. The highest SMR of lung cancer was observed in miners who smoked.ConclusionThe results suggested excessive cause-specific mortality, in particular from lung cancer and respiratory diseases, in the cohort, which was associated with exposure to chrysotile asbestos.