Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests.
Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests.
复制标题
DOI：
10.1136/gutjnl-2011-300843
复制
发表时间：
2012-10
期刊：
影响因子：
24.5
通讯作者：
English Bowel Cancer Screening Evaluation Committee
中科院分区：
文献类型：
--
作者：
Logan RF;Patnick J;Nickerson C;Coleman L;Rutter MD;von Wagner C;English Bowel Cancer Screening Evaluation Committee
英国的肠癌筛查项目于2006年开始实施，目标是到2009年12月在整个英格兰全面推广。年龄在60-69岁之间的受试者每2年进行3次愈创木粪便潜血检查（6个窗口）。该计划旨在使应邀接受筛检者的结直肠癌死亡率降低16%。所有有资格接受英国国民健康服务筛查的受试者都被纳入一个数据库，该数据库由覆盖约98%英格兰人口的国民健康服务登记数据填充。本分析仅针对受邀参加第一轮（普遍）筛查的受试者。截至2008年10月，近210万人被邀请参加，其中49.6%的男性和54.4%的女性被邀请返回测试。在管理该项目的四个省级中心，吸收率在55-60%之间，但在伦敦中心较低（40%）。在108万份返回的检测报告中，2.5%的男性和1.5%的女性检测结果异常。17518例（10608例男性，6910例女性）接受了调查，其中98%首次接受结肠镜检查。癌症（n=1772）和高风险腺瘤（n=6543）分别在11.6%和43%的男性和7.8%和29%的女性中被发现。71%的癌症是“早期”（10%的息肉癌，32%的Dukes A， 30%的Dukes B）， 77%的癌症是左侧的（29%的直肠癌，45%的乙状结肠），只有14%的癌症是右侧的，而英国癌症登记的预期数字是67%，左侧和右侧分别是24%。在英国的第一轮筛选中，摄取和粪便隐血测试阳性与试点和最初的欧洲试验一致。虽然在诊断时癌症分期有预期的改善，但左侧癌症的比例高于预期。
The Bowel Cancer Screening Programme in England began operating in 2006 with the aim of full roll out across England by December 2009. Subjects aged 60–69 are being invited to complete three guaiac faecal occult blood tests (6 windows) every 2 years. The programme aims to reduce mortality from colorectal cancer by 16% in those invited for screening. All subjects eligible for screening in the National Health Service in England are included on one database, which is populated from National Health Service registration data covering about 98% of the population of England. This analysis is only of subjects invited to participate in the first (prevalent) round of screening. By October 2008 almost 2.1 million had been invited to participate, with tests being returned by 49.6% of men and 54.4% of women invited. Uptake ranged between 55–60% across the four provincial hubs which administer the programme but was lower in the London hub (40%). Of the 1.08 million returning tests 2.5% of men and 1.5% of women had an abnormal test. 17 518 (10 608 M, 6910 F) underwent investigation, with 98% having a colonoscopy as their first investigation. Cancer (n=1772) and higher risk adenomas (n=6543) were found in 11.6% and 43% of men and 7.8% and 29% of women investigated, respectively. 71% of cancers were ‘early’ (10% polyp cancer, 32% Dukes A, 30% Dukes B) and 77% were left-sided (29% rectal, 45% sigmoid) with only 14% being right-sided compared with expected figures of 67% and 24% for left and right side from UK cancer registration. In this first round of screening in England uptake and fecal occult blood test positivity was in line with that from the pilot and the original European trials. Although there was the expected improvement in cancer stage at diagnosis, the proportion with left-sided cancers was higher than expected.
登录
查看更多内容
影响因子：
7.7
作者：
von Wagner, Christian;Baio, Gianluca;Wardle, Jane
通讯作者：
Wardle, Jane
影响因子：
105.7
作者：
Steele, RJC
通讯作者：
Steele, RJC
影响因子：
2.9
作者：
Steele, R. J. C.;Kostourou, I.;Fraser, C.
通讯作者：
Fraser, C.
影响因子：
29.4
作者：
van Rossum, Leo G.;van Rijn, Anne F.;Dekker, Evelien
通讯作者：
Dekker, Evelien
影响因子：
2.9
作者：
Zajac, I. T.;Whibley, A. H.;Young, G. P.
通讯作者：
Young, G. P.