Pomegranate derived products for cancer chemoprevention.
Pomegranate derived products for cancer chemoprevention.
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用于癌症化学预防的石榴衍生产品。
DOI：
10.1016/j.semcancer.2007.05.004
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发表时间：
2007
影响因子：
14.5
通讯作者：
Mukhtar,Hasan
中科院分区：
文献类型：
--
作者：
Syed,DeebaN;Afaq,Farrukh;Mukhtar,Hasan
由于晚期转移性癌症的治疗选择仍然不足，开发有效的预防癌症的方法已成为减少癌症负担的重要目标。其中一种策略是通过化学预防，最好是使用无毒的饮食物质和植物产品。几个世纪以来，由于其药用特性而被使用，现在被认为是一种潜在的化学预防和抗癌剂。越来越多的证据强调了石榴在体外和体内动物模型中的癌症预防功效。新出现的数据为建立针对各种人类癌症的基于新机制的化学预防策略所需的分子框架提供了新的见解。
Because treatment options for advanced metastasized cancers remain inadequate, developing effective approaches for the prevention of cancer has become an important goal to reduce cancer burden. One such strategy is through chemoprevention, preferably by the use of non-toxic dietary substances and botanical products. Pomegranate, used for centuries for its medicinal properties is now being recognized as a potential chemopreventive and anticancer agent. Increasing body of evidence has underscored the cancer preventive efficacy of pomegranate both in vitro and in vivo animal models. The emerging data provide new insights into the molecular framework needed to establish novel mechanism-based chemopreventive strategies for various human cancers.