Low levels of corticotropin-releasing hormone during early pregnancy are associated with precocious maturation of the human fetus.
Low levels of corticotropin-releasing hormone during early pregnancy are associated with precocious maturation of the human fetus.
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DOI：
10.1159/000191213
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发表时间：
2008
影响因子：
2.9
通讯作者：
Sandman CA
中科院分区：
文献类型：
--
作者：
Class QA;Buss C;Davis EP;Gierczak M;Pattillo C;Chicz-DeMet A;Sandman CA
妊娠最后三个月胎盘促肾上腺皮质激素释放激素（pCRH）升高与早产风险增加相关。关于人类胎儿在妊娠早期暴露于高水平pCRH的后果知之甚少。138名孕妇在妊娠15、20和25周时至少测量一次pCRH水平。在妊娠25周时，胎儿心率（FHR）对惊人的振动声刺激（VAS）的反应被记录为成熟指数。pCRH水平在妊娠15周，但在没有后来的点，预测胎心率反应的VAS。妊娠15周时暴露于最低浓度pCRH的胎儿对VAS表现出可区分的反应，而暴露于较高水平pCRH的胎儿则无反应。研究结果表明，在妊娠早期暴露于低水平的pCRH可能是最佳的，并与反应模式相关，表明更成熟。
Elevation in placental corticotropin-releasing hormone (pCRH) during the last trimester of pregnancy has been associated with an increased risk for preterm delivery. Less is known about the consequences for the human fetus exposed to high levels of pCRH early in pregnancy. pCRH levels were measured in 138 pregnant women at least once at 15, 20 and 25 weeks of gestation. At 25 weeks of gestation, fetal heart rate (FHR) responses to a startling vibroacoustic stimulus (VAS) were recorded as an index of maturity. pCRH levels at 15 weeks of gestation, but at no later point, predicted FHR responses to the VAS. Fetuses exposed to the lowest concentrations of pCRH at 15 weeks of gestation exhibited a distinguishable response to the VAS, whereas fetuses exposed to higher levels of pCRH did not respond. The findings suggest that exposure to low levels of pCRH early in gestation may be optimal and associated with a response pattern indicating greater maturity.