Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry
Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry
复制标题
DOI：
10.1073/pnas.93.18.9985
复制
发表时间：
1996-09-03
影响因子：
11.1
通讯作者：
Hichwa, RD
中科院分区：
文献类型：
--
作者：
Andreasen, NC;OLeary, DS;Hichwa, RD
精神分裂症患者表现出微妙的认知异常，这可能反映出在各种精神活动中快速协调步骤的困难。小脑与前额叶皮质相互作用，可能在协调运动和认知表现方面发挥作用。这项正电子发射断层扫描研究表明，前额-丘脑-小脑网络的存在，当正常受试者回忆复杂的叙事材料时，该网络被激活，但在精神分裂症患者中，当他们执行同样的任务时，该网络被激活。这些结果支持小脑在认知功能中的作用，并表明精神分裂症患者可能患有“认知功能障碍”，原因是前额叶-丘脑-小脑回路功能障碍。
Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps that occur in a variety of mental activities. Working interactively with the prefrontal cortex, the cerebellum may play a role in coordinating both motor and cognitive performance. This positron-emission tomography study suggests the presence of a prefrontal-thalamic-cerebellar network that is activated when normal subjects recall complex narrative material, but is dysfunctional in schizophrenic patients when they perform the same task. These results support a role for the cerebellum in cognitive functions and suggest that patients with schizophrenia may suffer from a ''cognitive dysmetria'' due to dysfunctional prefrontal-thalamic-cerebellar circuitry.