Geroprotectors and Skeletal Health: Beyond the Headlines.
Geroprotectors and Skeletal Health: Beyond the Headlines.
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DOI：
10.3389/fcell.2022.682045
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发表时间：
2022
影响因子：
5.5
通讯作者：
Bellantuono I
中科院分区：
文献类型：
--
作者：
Rayson A;Boudiffa M;Naveed M;Griffin J;Dall'Ara E;Bellantuono I
骨质疏松症和骨关节炎是肌肉骨骼系统最常见的与年龄相关的疾病。他们负责高水平的医疗保健使用，并且通常与合并症相关。衰老、炎症和自噬等衰老机制是这两种疾病的常见驱动因素，而针对这些机制的分子（老年保护剂）有可能预防这两种疾病及其并发症。然而，测试老年保护剂对骨骼和关节功效的研究还很少。现有的有限研究显示出预防和逆转骨质疏松症样疾病的有希望的结果。相比之下，迄今为止，对衰老小鼠骨关节炎样疾病发展的影响一直令人失望。在这里，我们回顾了文献并报告了有关老年保护剂对骨质疏松症和骨关节炎的影响的新数据，我们挑战了寿命延长与所有组织健康寿命延长相关的观念，并强调需要进行更彻底的研究来测试老年保护剂对衰老生物体骨骼健康的影响。
Osteoporosis and osteoarthritis are the most common age-related diseases of the musculoskeletal system. They are responsible for high level of healthcare use and are often associated with comorbidities. Mechanisms of ageing such as senescence, inflammation and autophagy are common drivers for both diseases and molecules targeting those mechanisms (geroprotectors) have potential to prevent both diseases and their co-morbidities. However, studies to test the efficacy of geroprotectors on bone and joints are scant. The limited studies available show promising results to prevent and reverse Osteoporosis-like disease. In contrast, the effects on the development of Osteoarthritis-like disease in ageing mice has been disappointing thus far. Here we review the literature and report novel data on the effect of geroprotectors for Osteoporosis and Osteoarthritis, we challenge the notion that extension of lifespan correlates with extension of healthspan in all tissues and we highlight the need for more thorough studies to test the effects of geroprotectors on skeletal health in ageing organisms.
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影响因子：
82.9
作者：
Farr JN;Xu M;Weivoda MM;Monroe DG;Fraser DG;Onken JL;Negley BA;Sfeir JG;Ogrodnik MB;Hachfeld CM;LeBrasseur NK;Drake MT;Pignolo RJ;Pirtskhalava T;Tchkonia T;Oursler MJ;Kirkland JL;Khosla S
通讯作者：
Khosla S
影响因子：
--
作者：
Carames, Beatriz;Taniguchi, Noboru;Seino, Daisuke;Blanco, Francisco J.;D'Lima, Darryl;Lotz, Martin
通讯作者：
Lotz, Martin
影响因子：
2.7
作者：
DiNicolantonio JJ;Bhutani J;O'Keefe JH
通讯作者：
O'Keefe JH
影响因子：
4.1
作者：
Farr, Joshua N.;Khosla, Sundeep
通讯作者：
Khosla, Sundeep
骨关节炎的炎症。
影响因子：
5.1
作者：
Goldring MB;Otero M
通讯作者：
Otero M